Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia

Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death. Here, we have identified a critical role of Cdk5 in cytoskeleton/foca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e75538-e75538
Hauptverfasser:	Bosutti, Alessandra, Qi, Jie, Pennucci, Roberta, Bolton, David, Matou, Sabine, Ali, Kamela, Tsai, Li-Huei, Krupinski, Jerzy, Petcu, Eugene B, Montaner, Joan, Al Baradie, Raid, Caccuri, Francesca, Caruso, Arnaldo, Alessandri, Giulio, Kumar, Shant, Rodriguez, Cristina, Martinez-Gonzalez, Jose, Slevin, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Adaptor Proteins, Signal Transducing - metabolism Analysis of Variance Angiogenesis Blotting, Western Brain research Calpain Cell adhesion & migration Cell cycle Cell Cycle Proteins - metabolism Cell death Cell Line Cell migration Cell Movement - drug effects Colorimetry Cyclin-dependent kinase 5 Cyclin-Dependent Kinase 5 - antagonists & inhibitors Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Cyclin-dependent kinases Cytoskeleton Cytoskeleton - drug effects DNA microarrays DNA Primers - genetics Gene expression Hospitals Humans Hypoxia Hypoxia - drug therapy Hypoxia - etiology Hypoxia - metabolism Immunoprecipitation Inhibition Kinases Laboratories Lamellipodia Localization Medicine MEF2 Transcription Factors - metabolism Microarray Analysis Microfilaments Microscopy, Fluorescence Musculoskeletal system Mutation, Missense - genetics Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Neurons Neurosciences Overexpression Peptides Peptides - metabolism Peptides - pharmacology Phosphorylation Pseudopodia Pseudopodia - metabolism Purines - pharmacology RNA Interference Roscovitine Science Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signaling siRNA Stroke Stroke - complications Substrates Talin Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!