Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques

Rhesus macaques (RMs) inoculated with live-attenuated Rev-Independent Nef¯ simian immunodeficiency virus (Rev-Ind Nef¯SIV) as adults or neonates controlled viremia to undetectable levels and showed no signs of immunodeficiency over 6-8 years of follow-up. We tested the capacity of this live-attenuat...

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Veröffentlicht in:	PloS one 2013, Vol.8 (9), p.e75556
Hauptverfasser:	Byrareddy, Siddappa N, Ayash-Rashkovsky, Mila, Kramer, Victor G, Lee, Sandra J, Correll, Mick, Novembre, Francis J, Villinger, Francois, Johnson, Welkin E, von Gegerfelt, Agneta, Felber, Barbara K, Ruprecht, Ruth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adults AIDS Animals Attenuation Bioinformatics Biology Cancer CCR5 protein Chemokines Drosophila Drug dosages Gene expression Gene Expression Profiling Gene Products, rev - genetics Genes Genomes HIV Human immunodeficiency virus Immune response Immune system Immunity, Innate - immunology Infections Innate immunity Insects Laboratories Macaca mulatta Medical research Monkeys & apes Mucosa Neonates Pathogenesis Receptors Schistosoma mansoni Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Immunodeficiency Virus Treatment Outcome Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - pharmacology Viral Regulatory and Accessory Proteins - genetics Viremia Viremia - immunology Viruses
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