AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina

Müller glia, the primary glial cell in the retina, provide structural and metabolic support for neurons and are essential for retinal integrity. Müller cells are closely involved in many retinal degenerative diseases, including macular telangiectasia type 2, in which impairment of central vision may...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e76075
Hauptverfasser:	Byrne, Leah C, Khalid, Fakhra, Lee, Trevor, Zin, Emilia A, Greenberg, Kenneth P, Visel, Meike, Schaffer, David V, Flannery, John G
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Ablation Techniques - methods Animal models Animals Apoptosis Blood Blood vessels Carrier Proteins - metabolism Cellular biology Defects Degenerative diseases Dependovirus - genetics Diabetes Electroretinography Ependymoglial Cells Eye (anatomy) Gene Transfer Techniques Genetic Vectors - administration & dosage Genetic Vectors - genetics Glial cells Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Glutamate-ammonia ligase Glutamate-Ammonia Ligase - metabolism Glutamine Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Image resolution Intravitreal Injections Metabolism Mice Neurosciences Opsins - metabolism Optogenetics Phagocytes Photoreceptors Proteins Retina Retina - cytology Retina - physiology Retinal degeneration Retinaldehyde Retinaldehyde-binding protein Rhodopsin Rodents Rosette Structure-function relationships Toxicity Vascular endothelial growth factor Visual perception
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