Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression

ATP-binding cassette transporter A1 (ABCA1) is critical in exporting cholesterol from macrophages and plays a protective role in the development of atherosclerosis. The purpose of this study was to investigate the effects of betulinic acid (BA), a pentacyclic triterpenoid, on ABCA1 expression and ch...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74782
Hauptverfasser:	Zhao, Guo-Jun, Tang, Shi-Lin, Lv, Yun-Cheng, Ouyang, Xin-Ping, He, Ping-Ping, Yao, Feng, Chen, Wu-Jun, Lu, Qian, Tang, Yan-Yan, Zhang, Min, Fu, Yuchang, Zhang, Da-Wei, Yin, Kai, Tang, Chao-Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Acids Activation Animals Apolipoprotein E Apolipoproteins Apolipoproteins E - deficiency Apolipoproteins E - metabolism Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - metabolism Atherosclerosis - pathology ATP Binding Cassette Transporter 1 - antagonists & inhibitors ATP Binding Cassette Transporter 1 - metabolism ATP-binding protein Betulinic acid Biological Transport - drug effects Body Weight - drug effects Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Cholesterol Cholesterol - metabolism Cytokines Development and progression Efflux Gene Expression Regulation - drug effects Genetic transcription Humans Inflammation Inhibition Kinases Laboratories Lipids Lipids - blood Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Male Metabolism Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Models, Biological NF-kappa B - metabolism NF-κB protein Nuclear transport Phosphorylation Protein Transport - drug effects Rodents Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Transcription Translocation Transporter Triterpenes - antagonists & inhibitors Triterpenes - pharmacology
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