Which T category of nasopharyngeal carcinoma may benefit most from volumetric modulated arc therapy compared with step and shoot intensity modulated radiation therapy
To compare volumetric modulated arc therapy (VMAT) with conventional step and shoot intensity modulated radiation therapy (s-IMRT) in nasopharyngeal carcinoma (NPC) patients, and identify which T category patient gains the maximum benefit from VMAT. Fifty-two patients that randomly selected from 205...
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| Veröffentlicht in: | PloS one 2013-09, Vol.8 (9), p.e75304 |
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| creator | Sun, Ying Guo, Rui Yin, Wen-Jing Tang, Ling-Long Yu, Xiao-Li Chen, Mo Qi, Zhen-Yu Liu, Meng-Zhong Ma, Jun |
| description | To compare volumetric modulated arc therapy (VMAT) with conventional step and shoot intensity modulated radiation therapy (s-IMRT) in nasopharyngeal carcinoma (NPC) patients, and identify which T category patient gains the maximum benefit from VMAT.
Fifty-two patients that randomly selected from 205 patients received VMAT at a single center were retrospectively replanned with s-IMRT. For a fair comparison, the planning target volume (PTV) coverage of the 2 plans was normalized to the same level. A standard planning constraint set was used; the constraints for the organs at risk (OARs) were individually adapted. The calculated doses to the PTV and OARs were compared for s-IMRT and VMAT plans generated using the Monaco treatment planning system.
VMAT and s-IMRT plans had similar PTV coverage and OAR sparing within all T categories. However, in stratified analysis, VMAT plans lead to better or similar sparing of the OARs in early T category patients; and lead to poorer sparing of the OARs in advanced T category patients (P |
| doi_str_mv | 10.1371/journal.pone.0075304 |
| format | Article |
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Fifty-two patients that randomly selected from 205 patients received VMAT at a single center were retrospectively replanned with s-IMRT. For a fair comparison, the planning target volume (PTV) coverage of the 2 plans was normalized to the same level. A standard planning constraint set was used; the constraints for the organs at risk (OARs) were individually adapted. The calculated doses to the PTV and OARs were compared for s-IMRT and VMAT plans generated using the Monaco treatment planning system.
VMAT and s-IMRT plans had similar PTV coverage and OAR sparing within all T categories. However, in stratified analysis, VMAT plans lead to better or similar sparing of the OARs in early T category patients; and lead to poorer sparing of the OARs in advanced T category patients (P<0.05). VMAT shows significant advantages for low dose burden (P<0.05) compared with s-IMRT. The delivery time per fraction for VMAT (424±64 s) was shorter than s-IMRT (778 ± 126 s, p<0.01).
VMAT provides similar dose coverage of the PTVs and similar/better normal tissue sparing in early T category NPC, and poorer OARs sparing in advanced T category NPC. And VMAT shows significant advantages for low dose burden and delivery time.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0075304</identifier><identifier>PMID: 24086503</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Background radiation ; Biopsy ; Cancer therapies ; Carcinoma ; Dose-Response Relationship, Radiation ; Exocrine glands ; Female ; Head & neck cancer ; Humans ; Laboratories ; Larynx ; Male ; Medical imaging ; Metastasis ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms - radiotherapy ; NMR ; Nuclear magnetic resonance ; Oncology ; Organs ; Parotid gland ; Patients ; Radiation ; Radiation dosage ; Radiation therapy ; Radiotherapy, Intensity-Modulated - methods ; Throat cancer ; Time Factors</subject><ispartof>PloS one, 2013-09, Vol.8 (9), p.e75304</ispartof><rights>2013 Sun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Sun et al 2013 Sun et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9cdbf59f0c5db08ef2e9230aa593e23240ca140f0f45e086cf4bd404cbd0b4bb3</citedby><cites>FETCH-LOGICAL-c526t-9cdbf59f0c5db08ef2e9230aa593e23240ca140f0f45e086cf4bd404cbd0b4bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783380/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783380/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24086503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Yin, Wen-Jing</creatorcontrib><creatorcontrib>Tang, Ling-Long</creatorcontrib><creatorcontrib>Yu, Xiao-Li</creatorcontrib><creatorcontrib>Chen, Mo</creatorcontrib><creatorcontrib>Qi, Zhen-Yu</creatorcontrib><creatorcontrib>Liu, Meng-Zhong</creatorcontrib><creatorcontrib>Ma, Jun</creatorcontrib><title>Which T category of nasopharyngeal carcinoma may benefit most from volumetric modulated arc therapy compared with step and shoot intensity modulated radiation therapy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To compare volumetric modulated arc therapy (VMAT) with conventional step and shoot intensity modulated radiation therapy (s-IMRT) in nasopharyngeal carcinoma (NPC) patients, and identify which T category patient gains the maximum benefit from VMAT.
Fifty-two patients that randomly selected from 205 patients received VMAT at a single center were retrospectively replanned with s-IMRT. For a fair comparison, the planning target volume (PTV) coverage of the 2 plans was normalized to the same level. A standard planning constraint set was used; the constraints for the organs at risk (OARs) were individually adapted. The calculated doses to the PTV and OARs were compared for s-IMRT and VMAT plans generated using the Monaco treatment planning system.
VMAT and s-IMRT plans had similar PTV coverage and OAR sparing within all T categories. However, in stratified analysis, VMAT plans lead to better or similar sparing of the OARs in early T category patients; and lead to poorer sparing of the OARs in advanced T category patients (P<0.05). VMAT shows significant advantages for low dose burden (P<0.05) compared with s-IMRT. The delivery time per fraction for VMAT (424±64 s) was shorter than s-IMRT (778 ± 126 s, p<0.01).
VMAT provides similar dose coverage of the PTVs and similar/better normal tissue sparing in early T category NPC, and poorer OARs sparing in advanced T category NPC. And VMAT shows significant advantages for low dose burden and delivery time.</description><subject>Adult</subject><subject>Aged</subject><subject>Background radiation</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Carcinoma</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Exocrine glands</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Larynx</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Carcinoma</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oncology</subject><subject>Organs</subject><subject>Parotid gland</subject><subject>Patients</subject><subject>Radiation</subject><subject>Radiation dosage</subject><subject>Radiation therapy</subject><subject>Radiotherapy, Intensity-Modulated - 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radiotherapy</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oncology</topic><topic>Organs</topic><topic>Parotid gland</topic><topic>Patients</topic><topic>Radiation</topic><topic>Radiation dosage</topic><topic>Radiation therapy</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Throat cancer</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Yin, Wen-Jing</creatorcontrib><creatorcontrib>Tang, Ling-Long</creatorcontrib><creatorcontrib>Yu, Xiao-Li</creatorcontrib><creatorcontrib>Chen, Mo</creatorcontrib><creatorcontrib>Qi, Zhen-Yu</creatorcontrib><creatorcontrib>Liu, Meng-Zhong</creatorcontrib><creatorcontrib>Ma, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Fifty-two patients that randomly selected from 205 patients received VMAT at a single center were retrospectively replanned with s-IMRT. For a fair comparison, the planning target volume (PTV) coverage of the 2 plans was normalized to the same level. A standard planning constraint set was used; the constraints for the organs at risk (OARs) were individually adapted. The calculated doses to the PTV and OARs were compared for s-IMRT and VMAT plans generated using the Monaco treatment planning system.
VMAT and s-IMRT plans had similar PTV coverage and OAR sparing within all T categories. However, in stratified analysis, VMAT plans lead to better or similar sparing of the OARs in early T category patients; and lead to poorer sparing of the OARs in advanced T category patients (P<0.05). VMAT shows significant advantages for low dose burden (P<0.05) compared with s-IMRT. The delivery time per fraction for VMAT (424±64 s) was shorter than s-IMRT (778 ± 126 s, p<0.01).
VMAT provides similar dose coverage of the PTVs and similar/better normal tissue sparing in early T category NPC, and poorer OARs sparing in advanced T category NPC. And VMAT shows significant advantages for low dose burden and delivery time.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24086503</pmid><doi>10.1371/journal.pone.0075304</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aged Background radiation Biopsy Cancer therapies Carcinoma Dose-Response Relationship, Radiation Exocrine glands Female Head & neck cancer Humans Laboratories Larynx Male Medical imaging Metastasis Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - radiotherapy NMR Nuclear magnetic resonance Oncology Organs Parotid gland Patients Radiation Radiation dosage Radiation therapy Radiotherapy, Intensity-Modulated - methods Throat cancer Time Factors |
| title | Which T category of nasopharyngeal carcinoma may benefit most from volumetric modulated arc therapy compared with step and shoot intensity modulated radiation therapy |
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