Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population

East Asian genome-wide association studies (GWAS) for type 2 diabetes identified 8 loci with genome-wide significance, and 2 loci with a borderline association. However, the associations of these loci except MAEA locus with type 2 diabetes have not been evaluated in independent East Asian cohorts. W...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e76317-e76317
Hauptverfasser:	Sakai, Kensuke, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Maeda, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Confidence intervals Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Endocrinology Genetic Loci - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes Genotype Hepatocyte nuclear factor 4 Homeostasis Humans Internal medicine Japan - epidemiology Kidney diseases Laboratories Loci Logistic Models Medicine Meta-analysis Metabolism Odds Ratio Polymorphism, Single Nucleotide - genetics Population Regression analysis Replication Science Single-nucleotide polymorphism Statistical analysis Studies University graduates
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