Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration

We explored the impact of Nox-2 in modulating inflammatory-mediated microglial responses in the 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD) model. Nox1 and Nox2 gene expression were found to increase in striatum, whereas a marked increase of Nox2 expression was observed in subst...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e75532
Hauptverfasser:	Hernandes, Marina S, Santos, Graziella D R, Café-Mendes, Cecília C, Lima, Larissa S, Scavone, Cristoforo, Munhoz, Carolina D, Britto, Luiz R G
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Activation Analysis Animals Apomorphine Apomorphine - pharmacology Biophysics Corpus Striatum - drug effects Corpus Striatum - pathology CYBB protein Degeneration Disease Disease Models, Animal Dopamine Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Enzymes Gene expression Inflammation Inflammation - genetics Inflammation - pathology Inflammatory response Inhibition Kinases Male Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Microglial cells Minocycline Minocycline - pharmacology Movement disorders NAD(P)H oxidase NADH, NADPH Oxidoreductases - genetics NADPH Oxidase 1 NADPH Oxidase 2 NADPH Oxidases - genetics Neostriatum Nerve Degeneration - chemically induced Nerve Degeneration - genetics Nerve Degeneration - pathology Nervous system Neurodegeneration Neurodegenerative diseases Neurons NF-kappa B - genetics NF-κB protein Oxidases Oxidative stress Oxidopamine - pharmacology Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Pharmacology Phenols (Class of compounds) Physiology Proteins Rodents Rotational behavior Signal transduction Signaling Substantia nigra Substantia Nigra - drug effects Substantia Nigra - pathology Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α
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