VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer

Vezatin (VEZT), an adherens junctions transmembrane protein, was identified as a putative tumor suppressor in our previous study. However, the role of VEZT in tumorigenesis remains elusive. We aimed to clarify its epigenetic regulation and biological functions in gastric cancer. In this study, we sh...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74409
Hauptverfasser:	Miao, Ruizhen, Guo, Xiaobo, Zhi, Qiaoming, Shi, Yulong, Li, Leping, Mao, Xuehui, Zhang, Li, Li, Chensheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens junctions Aged Aged, 80 and over Analysis Animals Cancer Carrier Proteins - genetics Carrier Proteins - metabolism Case-Control Studies Cdc42 protein Cell adhesion & migration Cell cycle Cell division Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chromatin Cluster Analysis Disease Models, Animal DNA Methylation DNA microarrays Epigenetic inheritance Epigenetics Female Gastric cancer Gastrointestinal surgery Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Silencing Genes Growth Health aspects Helicobacter Infections - genetics Helicobacter pylori Humans Immunoprecipitation Infection Infections Lasers Lymphatic Metastasis Male Membrane Proteins - genetics Membrane Proteins - metabolism Metastases Methylation Mice Middle Aged Patients Polymerase chain reaction Reproducibility of Results Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology Target recognition Tissues Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Burden Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumorigenesis Tumorigenicity Tumors Xenograft Model Antitumor Assays
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