Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers

MicroRNAs circulating in the blood, stabilized by complexation with proteins and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as biomarkers. The consequences of their differential association with lipids/vesicles for their stability and use as biomarkers are larg...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e75184-e75184
Hauptverfasser:	Köberle, Verena, Pleli, Thomas, Schmithals, Christian, Augusto Alonso, Eduardo, Haupenthal, Jörg, Bönig, Halvard, Peveling-Oberhag, Jan, Biondi, Ricardo M, Zeuzem, Stefan, Kronenberger, Bernd, Waidmann, Oliver, Piiper, Albrecht
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological markers Biomarkers Biomarkers, Tumor - blood Blood Blood cells Blood circulation Enzyme Inhibitors - pharmacology Enzymes Erythrocytes - metabolism Healthy Volunteers Hemolysis Hepatitis Hospitals Humans Inhibitors Interferon Kinases Lipids Liver cancer Medicine MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - chemistry miRNA Plasma Proteins Reverse Transcriptase Polymerase Chain Reaction Ribonuclease Ribonuclease, Pancreatic - antagonists & inhibitors Ribonucleic acid RNA RNA Stability Serum - metabolism Stability Studies Transcription (Genetics) Urine Vesicles
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