New insights into the binding and catalytic mechanisms of Bacillus thuringiensis lactonase: insights into B. thuringiensis AiiA mechanism

The lactonase enzyme (AiiA) produced by Bacillus thuringiensis serves to degrade autoinducer-1 (AI-1) signaling molecules in what is an evolved mechanism by which to compete with other bacteria. Bioassays have been previously performed to determine whether the AI-1 aliphatic tail lengths have any ef...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e75395-e75395
Hauptverfasser:	Charendoff, Marc N, Shah, Halie P, Briggs, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Analysis Antibiotics Bacillus thuringiensis Bacillus thuringiensis - enzymology Bacillus thuringiensis - genetics Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioassays Biochemistry Biofilms Biological activity Biology Carbonyls Catalysis Catalytic activity Catalytic Domain Enzymes Gene expression Gram-negative bacteria Homoserine lactones Ionization Lactones Metabolism Metalloendopeptidases - chemistry Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Molecular dynamics Molecular Dynamics Simulation Protein Structure, Secondary Proteins Pseudomonas aeruginosa Reagents Signaling Simulation Studies Substrates Tails Zinc
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