Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative/nitrosative cellular stress

The mechanism(s) by which cells can sense exogenous oxidants that may contribute to intracellular oxidative/nitrosative stress is not clear. The objective of this study was to determine how cells might respond to exogenous oxidants to potentially initiate, propagate and/or maintain inflammation asso...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73840
Hauptverfasser:	Karki, Rajendra, Igwe, Orisa J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alkaline phosphatase Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Antioxidants Antioxidants - pharmacology Cell culture Cell Engineering Cell Survival - drug effects Cellular stress response Chromates - pharmacology Chronic illnesses Culture media Cytokines Disease Embryos Gene Expression Regulation Genes HEK293 Cells Humans IL-1β Inflammation Inhibitors Interleukin-1beta - genetics Interleukin-1beta - metabolism Male Mice NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Organometallic Compounds - pharmacology Oxidants Oxidants - pharmacology Oxidative Stress Oxidizing agents Pain Pain - physiopathology Pain - prevention & control Pain Threshold Peroxides - pharmacology Phagocytes Phosphatases Reactive Nitrogen Species - antagonists & inhibitors Reactive Nitrogen Species - metabolism Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Reporter gene Salicylates - pharmacology Signal Transduction Signaling Stimulation TLR2 protein TLR4 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Toxicology Transcription (Genetics) Tumor necrosis factor-α
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