Inflammatory mediators influence the expression of nociceptin and its receptor in human whole blood cultures

Nociceptin/orphanin FQ and its receptor (NOP) are involved in immune responses, inflammation and pain processing. The aim of this study was to investigate the modulation of NOP and prepro-nociceptin (PNoc), the precursor of nociceptin, by inflammatory mediators in human whole blood. Peripheral blood...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74138-e74138
Hauptverfasser:	Zhang, Lan, Stuber, Frank, Stamer, Ulrike M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesiology Antibodies Blood Blood cells Blood tests Brain research Cytokines Drug dosages Endogenous opioids Enzyme-linked immunosorbent assay Erythrocytes Experiments Feedback loops Female Gene expression Humans Immune response Immune system Immunity - drug effects Immunoglobulins Immunologic factors Incubation Inflammation Interferon Interferon-gamma - pharmacology Interleukin Interleukin 10 Interleukin-10 - pharmacology Interleukin-1beta - pharmacology Leukocytes Ligands Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medical research Middle Aged Mitogens Modulation Narcotics Negative feedback Nociceptin Opioid Peptides - blood Pain Peripheral blood Polymerase chain reaction Proteins RNA Rodents Studies Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α White blood cells γ-Interferon
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