Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010
Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Re...
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| creator | Panozzo, Catherine A Becker-Dreps, Sylvia Pate, Virginia Jonsson Funk, Michele Stürmer, Til Weber, David J Brookhart, M Alan |
| description | Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Research Databases, 2006-2010. The analysis was restricted to infants residing in states without state-funded rotavirus vaccination programs. We computed summary statistics and used multivariable regression to assess the association between patient-, provider-, and ecologic-level variables of rotavirus vaccine receipt and series completion. Approximately 69% of 594,117 eligible infants received at least one dose of rotavirus vaccine from 2006-2010. Most infants received the rotavirus vaccines at the recommended ages, but more infants completed the series for monovalent rotavirus vaccine than pentavalent rotavirus vaccine or a mix of the vaccines (87% versus 79% versus 73%, P |
| doi_str_mv | 10.1371/journal.pone.0073825 |
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We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Research Databases, 2006-2010. The analysis was restricted to infants residing in states without state-funded rotavirus vaccination programs. We computed summary statistics and used multivariable regression to assess the association between patient-, provider-, and ecologic-level variables of rotavirus vaccine receipt and series completion. Approximately 69% of 594,117 eligible infants received at least one dose of rotavirus vaccine from 2006-2010. Most infants received the rotavirus vaccines at the recommended ages, but more infants completed the series for monovalent rotavirus vaccine than pentavalent rotavirus vaccine or a mix of the vaccines (87% versus 79% versus 73%, P<0.001). In multivariable analyses, the strongest predictors of rotavirus vaccine series initiation and completion were receipt of the diphtheria, tetanus and acellular pertussis vaccine (Initiation: RR = 7.91, 95% CI = 7.69-8.13; Completion: RR = 1.26, 95% CI = 1.23-1.29), visiting a pediatrician versus family physician (Initiation: RR = 1.51, 95% CI = 1.49-1.52; Completion: RR = 1.13, 95% CI = 1.11-1.14), and living in a large metropolitan versus smaller metropolitan, urban, or rural area. We observed rapid diffusion of the rotavirus vaccine in routine practice; however, approximately one-fifth of infants did not receive at least one dose of vaccine as recently as 2010. Interventions to increase rotavirus vaccine coverage should consider targeting family physicians and encouraging completion of the vaccine series.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0073825</identifier><identifier>PMID: 24066076</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Births ; Child, Preschool ; Children ; Codes ; Diphtheria ; Disease control ; Disease prevention ; Drug dosages ; Ecological monitoring ; Epidemiology ; Family medicine ; Female ; Gastroenteritis ; Health care policy ; Hepatitis ; Humans ; Immunization ; Infant ; Infants ; Insurance coverage ; Male ; Medical personnel ; Medical research ; Multivariate Analysis ; Online databases ; Pertussis ; Physicians ; Property and casualty insurance industry ; Public health ; Regression analysis ; Rotavirus ; Rotavirus - pathogenicity ; Rotavirus Infections - immunology ; Rotavirus Infections - prevention & control ; Rotavirus Vaccines - immunology ; Rotavirus Vaccines - therapeutic use ; Rural areas ; Statistical analysis ; Studies ; Tetanus ; Vaccination ; Vaccines ; Viruses</subject><ispartof>PloS one, 2013-09, Vol.8 (9), p.e73825-e73825</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Panozzo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Panozzo et al 2013 Panozzo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-79dc4565b72f4378dee2c4de72157beb063469287ccbd268c52638fbe7e8bdd03</citedby><cites>FETCH-LOGICAL-c692t-79dc4565b72f4378dee2c4de72157beb063469287ccbd268c52638fbe7e8bdd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774785/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774785/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24066076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panozzo, Catherine A</creatorcontrib><creatorcontrib>Becker-Dreps, Sylvia</creatorcontrib><creatorcontrib>Pate, Virginia</creatorcontrib><creatorcontrib>Jonsson Funk, Michele</creatorcontrib><creatorcontrib>Stürmer, Til</creatorcontrib><creatorcontrib>Weber, David J</creatorcontrib><creatorcontrib>Brookhart, M Alan</creatorcontrib><title>Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Research Databases, 2006-2010. The analysis was restricted to infants residing in states without state-funded rotavirus vaccination programs. We computed summary statistics and used multivariable regression to assess the association between patient-, provider-, and ecologic-level variables of rotavirus vaccine receipt and series completion. Approximately 69% of 594,117 eligible infants received at least one dose of rotavirus vaccine from 2006-2010. Most infants received the rotavirus vaccines at the recommended ages, but more infants completed the series for monovalent rotavirus vaccine than pentavalent rotavirus vaccine or a mix of the vaccines (87% versus 79% versus 73%, P<0.001). In multivariable analyses, the strongest predictors of rotavirus vaccine series initiation and completion were receipt of the diphtheria, tetanus and acellular pertussis vaccine (Initiation: RR = 7.91, 95% CI = 7.69-8.13; Completion: RR = 1.26, 95% CI = 1.23-1.29), visiting a pediatrician versus family physician (Initiation: RR = 1.51, 95% CI = 1.49-1.52; Completion: RR = 1.13, 95% CI = 1.11-1.14), and living in a large metropolitan versus smaller metropolitan, urban, or rural area. We observed rapid diffusion of the rotavirus vaccine in routine practice; however, approximately one-fifth of infants did not receive at least one dose of vaccine as recently as 2010. Interventions to increase rotavirus vaccine coverage should consider targeting family physicians and encouraging completion of the vaccine series.</description><subject>Births</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Codes</subject><subject>Diphtheria</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Drug dosages</subject><subject>Ecological monitoring</subject><subject>Epidemiology</subject><subject>Family medicine</subject><subject>Female</subject><subject>Gastroenteritis</subject><subject>Health care policy</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infants</subject><subject>Insurance coverage</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medical research</subject><subject>Multivariate Analysis</subject><subject>Online databases</subject><subject>Pertussis</subject><subject>Physicians</subject><subject>Property and casualty insurance industry</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Rotavirus</subject><subject>Rotavirus - pathogenicity</subject><subject>Rotavirus Infections - immunology</subject><subject>Rotavirus Infections - prevention & control</subject><subject>Rotavirus Vaccines - immunology</subject><subject>Rotavirus Vaccines - therapeutic use</subject><subject>Rural areas</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tetanus</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLgijYMV9N2hthWfwYWFhxXb0MaXI607WTjEk6uP_ezEx3mcpeSC4aTp_znpNz3ix7jtEMU4HfX7vBW9XP1s7CDCFBK1I-yI5xTUnBCaIPD-5H2ZMQrhEqacX54-yIMMQ5Evw4-_lVxQjehty1uXdRbTo_hHyjtO4s5MM6ql-QK2vyIUDe2Xztu42K0N8UnQ2DB5NfXaZ4q2wM73KCEC8Iwuhp9qhVfYBn4_cku_r08fvZl-L84vP87PS80LwmsRC10azkZSNIy6ioDADRzIAguBQNNIhTlsBKaN0YwitdEk6rtgEBVWMMoifZy73uundBjjMJEjNKEasJFYmY7wnj1LVM7a-Uv5FOdXIXcH4hlY-d7kGauiWcc61bxRktcdXoynBTE4EboFWZtD6M1YZmBUaDjV71E9HpH9st5cJtJBWCiZ3Am1HAu98DhChXXdDQ98qCG3Z9C4wFq7d9v_oHvf91I7VQ6QFpDy7V1VtReZoqEsbTqhM1u4dKx8Cq08lAbZfik4S3k4TERPgTF2oIQc4vv_0_e_Fjyr4-YJeg-rgMrh9i52yYgmwPau9C8NDeDRkjufX_7TTk1v9y9H9Ke3G4oLukW8PTv25X_g4</recordid><startdate>20130916</startdate><enddate>20130916</enddate><creator>Panozzo, Catherine A</creator><creator>Becker-Dreps, Sylvia</creator><creator>Pate, Virginia</creator><creator>Jonsson Funk, Michele</creator><creator>Stürmer, Til</creator><creator>Weber, David J</creator><creator>Brookhart, M Alan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130916</creationdate><title>Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010</title><author>Panozzo, Catherine A ; Becker-Dreps, Sylvia ; Pate, Virginia ; Jonsson Funk, Michele ; Stürmer, Til ; Weber, David J ; Brookhart, M Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-79dc4565b72f4378dee2c4de72157beb063469287ccbd268c52638fbe7e8bdd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Births</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Codes</topic><topic>Diphtheria</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Drug dosages</topic><topic>Ecological monitoring</topic><topic>Epidemiology</topic><topic>Family medicine</topic><topic>Female</topic><topic>Gastroenteritis</topic><topic>Health care policy</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Infants</topic><topic>Insurance coverage</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medical research</topic><topic>Multivariate Analysis</topic><topic>Online databases</topic><topic>Pertussis</topic><topic>Physicians</topic><topic>Property and casualty insurance industry</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Rotavirus</topic><topic>Rotavirus - pathogenicity</topic><topic>Rotavirus Infections - immunology</topic><topic>Rotavirus Infections - prevention & control</topic><topic>Rotavirus Vaccines - immunology</topic><topic>Rotavirus Vaccines - therapeutic use</topic><topic>Rural areas</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tetanus</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panozzo, Catherine A</creatorcontrib><creatorcontrib>Becker-Dreps, Sylvia</creatorcontrib><creatorcontrib>Pate, Virginia</creatorcontrib><creatorcontrib>Jonsson Funk, Michele</creatorcontrib><creatorcontrib>Stürmer, Til</creatorcontrib><creatorcontrib>Weber, David J</creatorcontrib><creatorcontrib>Brookhart, M Alan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panozzo, Catherine A</au><au>Becker-Dreps, Sylvia</au><au>Pate, Virginia</au><au>Jonsson Funk, Michele</au><au>Stürmer, Til</au><au>Weber, David J</au><au>Brookhart, M Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-09-16</date><risdate>2013</risdate><volume>8</volume><issue>9</issue><spage>e73825</spage><epage>e73825</epage><pages>e73825-e73825</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Research Databases, 2006-2010. The analysis was restricted to infants residing in states without state-funded rotavirus vaccination programs. We computed summary statistics and used multivariable regression to assess the association between patient-, provider-, and ecologic-level variables of rotavirus vaccine receipt and series completion. Approximately 69% of 594,117 eligible infants received at least one dose of rotavirus vaccine from 2006-2010. Most infants received the rotavirus vaccines at the recommended ages, but more infants completed the series for monovalent rotavirus vaccine than pentavalent rotavirus vaccine or a mix of the vaccines (87% versus 79% versus 73%, P<0.001). In multivariable analyses, the strongest predictors of rotavirus vaccine series initiation and completion were receipt of the diphtheria, tetanus and acellular pertussis vaccine (Initiation: RR = 7.91, 95% CI = 7.69-8.13; Completion: RR = 1.26, 95% CI = 1.23-1.29), visiting a pediatrician versus family physician (Initiation: RR = 1.51, 95% CI = 1.49-1.52; Completion: RR = 1.13, 95% CI = 1.11-1.14), and living in a large metropolitan versus smaller metropolitan, urban, or rural area. We observed rapid diffusion of the rotavirus vaccine in routine practice; however, approximately one-fifth of infants did not receive at least one dose of vaccine as recently as 2010. Interventions to increase rotavirus vaccine coverage should consider targeting family physicians and encouraging completion of the vaccine series.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24066076</pmid><doi>10.1371/journal.pone.0073825</doi><tpages>e73825</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Births Child, Preschool Children Codes Diphtheria Disease control Disease prevention Drug dosages Ecological monitoring Epidemiology Family medicine Female Gastroenteritis Health care policy Hepatitis Humans Immunization Infant Infants Insurance coverage Male Medical personnel Medical research Multivariate Analysis Online databases Pertussis Physicians Property and casualty insurance industry Public health Regression analysis Rotavirus Rotavirus - pathogenicity Rotavirus Infections - immunology Rotavirus Infections - prevention & control Rotavirus Vaccines - immunology Rotavirus Vaccines - therapeutic use Rural areas Statistical analysis Studies Tetanus Vaccination Vaccines Viruses |
| title | Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010 |
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