Phosphoantigen/IL2 Expansion and Differentiation of V[gamma]2V[delta]2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

  Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted mechanistic studies to determine whether earlier expansion/differentiation of...

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Veröffentlicht in:PLoS pathogens 2013-08, Vol.9 (8)
Hauptverfasser: Chen, Crystal, Yao, Shuyu, Huang, Dan, Wei, Huiyong, Sicard, Helene, Zeng, Gucheng, Jomaa, Hassan, Larsen, Michelle, Jr, William, Wang, Richard, Letvin, Norman, Shen, Yun, Qiu, Liyou, Shen, Ling, Chen, Zheng
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Sprache:eng
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