Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity

Gastrointestinal nematode parasites infect over 1 billion humans, with little evidence for generation of sterilising immunity. These helminths are highly adapted to their mammalian host, following a developmental program through successive niches, while effectively down-modulating host immune respon...

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Veröffentlicht in:	PLoS pathogens 2013-08, Vol.9 (8), p.e1003492-e1003492
Hauptverfasser:	Hewitson, James P, Ivens, Al C, Harcus, Yvonne, Filbey, Kara J, McSorley, Henry J, Murray, Janice, Bridgett, Stephen, Ashford, David, Dowle, Adam A, Maizels, Rick M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Helminth - analysis Antibodies, Helminth - immunology Antigens Antigens, Helminth - immunology Antigens, Helminth - metabolism Biology Blotting, Western Chromatography, Liquid Computational Biology Eggs Electrophoresis, Gel, Two-Dimensional Enzyme-Linked Immunosorbent Assay Female Gene Expression Profiling Health aspects Helminth Proteins - immunology Helminth Proteins - metabolism Host-Parasite Interactions Immunization Immunoprecipitation Larva - immunology Larva - metabolism Larval development Medicine Mice Mice, Inbred C57BL Mice, Inbred CBA Nematode Infections - immunology Nematode Infections - parasitology Nematospiroides dubius - growth & development Nematospiroides dubius - immunology Parasites Peptides Physiological aspects Proteins Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Vaccination
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