Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni

Cys-loop ligand-gated ion channels (LGICs) mediate fast ionotropic neurotransmission. They are proven drug targets in nematodes and arthropods, but are poorly characterized in flatworms. In this study, we characterized the anion-selective, non-acetylcholine-gated Cys-loop LGICs from Schistosoma mans...

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Veröffentlicht in:	PLoS pathogens 2013-08, Vol.9 (8), p.e1003586
Hauptverfasser:	Dufour, Vanessa, Beech, Robin N, Wever, Claudia, Dent, Joseph A, Geary, Timothy G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding sites Biology Chloride Channels - genetics Chloride Channels - metabolism Circulatory system Cloning Cloning, Molecular Colleges & universities Disease Drug resistance Experiments Female Glutamic Acid - genetics Glutamic Acid - metabolism Helminth Proteins - genetics Helminth Proteins - metabolism Infections Insecticides Ligands Mice Molecular Sequence Data Nematodes Oocytes - cytology Oocytes - metabolism Phylogenetics Schistosoma mansoni - genetics Schistosoma mansoni - metabolism Signal transduction Signal Transduction - physiology
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