X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis

Pseudomonas aeruginosa infections are associated with high mortality rates and occur in diverse conditions including pneumonias, cystic fibrosis and neutropenia. Quorum sensing, mediated by small molecules including N-(3-oxo-dodecanoyl) homoserine lactone (C12), regulates P. aeruginosa growth and vi...

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Veröffentlicht in:	PLoS pathogens 2013-08, Vol.9 (8), p.e1003576
Hauptverfasser:	Valentine, Cathleen D, Anderson, Marc O, Papa, Feroz R, Haggie, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - genetics 4-Butyrolactone - metabolism Animals Antimicrobial agents Apoptosis Bacteriology Binding proteins Biology Caspases - genetics Caspases - metabolism Chronic illnesses Cytotoxicity Cytotoxins - genetics Cytotoxins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug dosages Endoplasmic reticulum Endoplasmic Reticulum Stress Enzyme Activation - genetics Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Health aspects Host-parasite relationships Kinases MAP Kinase Signaling System - genetics Medicine Mice Mice, Knockout Microbiology Mortality p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Physiological aspects Polypeptides Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - pathogenicity Regulatory Factor X Transcription Factors Serine Transcription Factors - genetics Transcription Factors - metabolism X-Box Binding Protein 1
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