The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen

PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(-/-) mice infected with T. gondii exhibited higher parasite load and worsened histopathology in the eye and brain compared...

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Veröffentlicht in:	PLoS pathogens 2013-08, Vol.9 (8), p.e1003557-e1003557
Hauptverfasser:	Ogolla, Pauline Sebby, Portillo, Jose-Andres C, White, Christine L, Patel, Krupen, Lamb, Bruce, Sen, Ganes C, Subauste, Carlos S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - genetics Biology Biotechnology Brain research CD40 Antigens - genetics CD40 Antigens - metabolism Cytokines - genetics Cytokines - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Experiments Immune system Infections Kinases Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Microglia - metabolism Microglia - pathology Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Parasites Phosphorylation Phosphorylation - genetics Proteins Rodents Signal Transduction Toxoplasma - genetics Toxoplasma - metabolism Toxoplasmosis - enzymology Toxoplasmosis - genetics Toxoplasmosis - pathology Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism Viruses
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