The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow

In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani (3 days post-infection) following cutaneous infection and a 16-fold decrease in lymph node barrier function (p

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Bibliographische Detailangaben
Veröffentlicht in:	PLoS neglected tropical diseases 2013-08, Vol.7 (8), p.e2329-e2329
Hauptverfasser:	Ibrahim, Marwa K, Barnes, Jeffrey L, Anstead, Gregory M, Jimenez, Fabio, Travi, Bruno L, Peniche, Alex G, Osorio, E Yaneth, Ahuja, Seema S, Melby, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Development and progression Disease Models, Animal Female Immune response Leishmania donovani - immunology Leishmaniasis Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - pathology Lymph Nodes - immunology Lymphatic system Malnutrition Malnutrition - complications Medical research Mice Mice, Inbred BALB C Parasites Parasitic diseases Phagocytes Phagocytes - immunology Physiological aspects Testing Time Factors
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Beschreibung
Zusammenfassung:	In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani (3 days post-infection) following cutaneous infection and a 16-fold decrease in lymph node barrier function (p
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0002329