Pathogenic mouse hepatitis virus or poly(I:C) induce IL-33 in hepatocytes in murine models of hepatitis

The IL-33/ST2 axis is known to be involved in liver pathologies. Although, the IL-33 levels increased in sera of viral hepatitis patients in human, the cellular sources of IL-33 in viral hepatitis remained obscure. Therefore, we aimed to investigate the expression of IL-33 in murine fulminant hepati...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74278
Hauptverfasser:	Arshad, Muhammad Imran, Patrat-Delon, Solène, Piquet-Pellorce, Claire, L'helgoualc'h, Annie, Rauch, Michel, Genet, Valentine, Lucas-Clerc, Catherine, Bleau, Christian, Lamontagne, Lucie, Samson, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens Antigens, CD1d - genetics Antigens, CD1d - immunology CD1d antigen Cytokines D-Galactosamine Endothelial cells Endothelial Cells - immunology Endothelial Cells - pathology Endothelial Cells - virology Endothelium, Vascular - immunology Endothelium, Vascular - pathology Endothelium, Vascular - virology Galactosamine - administration & dosage Gene Deletion Gene Expression - immunology Health aspects Hepatitis Hepatitis - etiology Hepatitis - genetics Hepatitis - immunology Hepatitis - pathology Hepatitis, Viral, Animal - genetics Hepatitis, Viral, Animal - immunology Hepatitis, Viral, Animal - pathology Hepatitis, Viral, Animal - virology Hepatocytes Human health and pathology Infections Infectious diseases Inflammation Injury prevention Interleukin-33 Interleukins - genetics Interleukins - immunology Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - pathology Killer Cells, Natural - virology Life Sciences Liver Liver - immunology Liver - pathology Liver - virology Lymphocytes T Mice Mice, Knockout Murine hepatitis virus - immunology Murine hepatitis virus - pathogenicity Natural killer cells Natural Killer T-Cells - immunology Natural Killer T-Cells - pathology Natural Killer T-Cells - virology Poly (I:C) Poly I-C - administration & dosage Rodents TLR3 protein Toll-like receptors Tumor necrosis factor-TNF Viral infections Viruses
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