Potential role of mesenchymal stem cells in alleviating intestinal ischemia/reperfusion impairment

Transplantation of bone marrow mesenchymal stem cells (MSCs) provides a promising therapeutic efficiency for a variety of disorders caused by ischemia or reperfusion impairment. We have previously demonstrated the efficacy of MSCs in mitigating intestinal ischemia/reperfusion (I/R) injuries in rats,...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74468-e74468
Hauptverfasser:	Jiang, Haitao, Qu, Linlin, Dou, Rongrong, Lu, Lianfang, Bian, Sishan, Zhu, Weiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Bone marrow Bone marrow transplantation Cell proliferation Enzyme-Linked Immunosorbent Assay Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Regulation Health aspects Hospitals Impairment Inflammation Inflammatory bowel disease Inflammatory response Injuries Injury prevention Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Intestine Intestines - blood supply Intestines - pathology Ischemia Kinases Laboratory animals Male Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Mucosa NF-κB protein Phosphorylation Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Reperfusion Reperfusion Injury - enzymology Reperfusion Injury - therapy Rodents Small intestine Stem cell transplantation Stem cells Surgery Transcription Factor RelA - metabolism Transplantation Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Y chromosomes
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