Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa
Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capa...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-09, Vol.8 (9), p.e74223 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 9 |
| container_start_page | e74223 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Martínez-Fernández de la Cámara, Cristina Salom, David Sequedo, Ma Dolores Hervás, David Marín-Lambíes, Cristina Aller, Elena Jaijo, Teresa Díaz-Llopis, Manuel Millán, José María Rodrigo, Regina |
| description | Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa. |
| doi_str_mv | 10.1371/journal.pone.0074223 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1432136468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478300744</galeid><doaj_id>oai_doaj_org_article_aac30e91cbe6429c84751d2c3a7e13e4</doaj_id><sourcerecordid>A478300744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-ea90a3cdf041aeb4b153240ca5756f84e6bc56cdae8e765545dd63d4f6e951543</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rr6D0QDguDFjEnz0fZmYVj8GFhY8Os2pMnpNEPb1CTV9d-bcbrLFBSkF6c5fc6b05c3y54TvCa0IG_3bvKD6tajG2CNccHynD7IzklF85XIMX148n6WPQlhjzGnpRCPs7OcYVHlJT3P_KaL4MEgNUTrbq1JdTVXFKKKU0B2QLEFpL5P4NKxnXrnE2_QCN6OLXjVobpzziDXoFFFC0MM6KeNLfIQ7WCjDWi0uz71XVBPs0eN6gI8m-tF9vX9uy9XH1fXNx-2V5vrlU67xRWoCiuqTYMZUVCzmnCa9taKF1w0JQNRay60UVBCIThn3BhBDWsEVJxwRi-yl0fdsXNBznYFSRjNCRVMlInYHgnj1F6O3vbK_5JOWfmn4fxOKh-t7kAqpSmGiugaBMsrXbKCE5NrqgogFA63Xc63TXUPRqd_Tb4sRJdfBtvKnfshaVHkWPAk8GoW8C45HeI_Vp6pnUpb2aFxSUz3Nmi5YUVJD0E4LLP-C5UeA73VKTCNTf3FwJvFQGIi3MadmkKQ28-f_p-9-bZkX5-wLagutsF1U8raEJYgO4LauxA8NPfOESwPeb9zQx7yLue8p7EXp67fD90FnP4GZjn9aQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1432136468</pqid></control><display><type>article</type><title>Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa</title><source>PubMed Central Free</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Martínez-Fernández de la Cámara, Cristina ; Salom, David ; Sequedo, Ma Dolores ; Hervás, David ; Marín-Lambíes, Cristina ; Aller, Elena ; Jaijo, Teresa ; Díaz-Llopis, Manuel ; Millán, José María ; Rodrigo, Regina</creator><contributor>Lewin, Alfred</contributor><creatorcontrib>Martínez-Fernández de la Cámara, Cristina ; Salom, David ; Sequedo, Ma Dolores ; Hervás, David ; Marín-Lambíes, Cristina ; Aller, Elena ; Jaijo, Teresa ; Díaz-Llopis, Manuel ; Millán, José María ; Rodrigo, Regina ; Lewin, Alfred</creatorcontrib><description>Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0074223</identifier><identifier>PMID: 24069283</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Antioxidants ; Antioxidants (Nutrients) ; Antioxidants - metabolism ; Apoptosis ; Aqueous Humor - metabolism ; Biomarkers ; Blindness ; Blood ; Blood & organ donations ; Case-Control Studies ; Cluster Analysis ; Consumption ; Covariance ; Cyclic GMP ; Cyclic GMP - metabolism ; Degeneration ; Enzymes ; Female ; Gene Expression ; Heme ; Heme Oxygenase-1 - genetics ; Hospitals ; Humans ; Leukocytes, Mononuclear - metabolism ; Machinery ; Machinery and equipment ; Male ; Markers ; Medical research ; Metabolism ; Metabolites ; Metabolome ; Middle Aged ; Multivariate analysis ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric-oxide synthase ; Nitrotyrosine ; Oxidants - metabolism ; Oxidative stress ; Oxygenase ; Pathogenesis ; Patients ; Peripheral blood ; Photoreceptors ; Plasma ; Retina ; Retinal degeneration ; Retinitis ; Retinitis pigmentosa ; Retinitis Pigmentosa - blood ; Retinitis Pigmentosa - metabolism ; Studies ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Superoxides ; Systemic diseases ; Thiobarbituric acid</subject><ispartof>PloS one, 2013-09, Vol.8 (9), p.e74223</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Martínez-Fernández de la Cámara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Martínez-Fernández de la Cámara et al 2013 Martínez-Fernández de la Cámara et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ea90a3cdf041aeb4b153240ca5756f84e6bc56cdae8e765545dd63d4f6e951543</citedby><cites>FETCH-LOGICAL-c692t-ea90a3cdf041aeb4b153240ca5756f84e6bc56cdae8e765545dd63d4f6e951543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772065/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772065/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24069283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lewin, Alfred</contributor><creatorcontrib>Martínez-Fernández de la Cámara, Cristina</creatorcontrib><creatorcontrib>Salom, David</creatorcontrib><creatorcontrib>Sequedo, Ma Dolores</creatorcontrib><creatorcontrib>Hervás, David</creatorcontrib><creatorcontrib>Marín-Lambíes, Cristina</creatorcontrib><creatorcontrib>Aller, Elena</creatorcontrib><creatorcontrib>Jaijo, Teresa</creatorcontrib><creatorcontrib>Díaz-Llopis, Manuel</creatorcontrib><creatorcontrib>Millán, José María</creatorcontrib><creatorcontrib>Rodrigo, Regina</creatorcontrib><title>Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa.</description><subject>Adult</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Antioxidants - metabolism</subject><subject>Apoptosis</subject><subject>Aqueous Humor - metabolism</subject><subject>Biomarkers</subject><subject>Blindness</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Case-Control Studies</subject><subject>Cluster Analysis</subject><subject>Consumption</subject><subject>Covariance</subject><subject>Cyclic GMP</subject><subject>Cyclic GMP - metabolism</subject><subject>Degeneration</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Heme</subject><subject>Heme Oxygenase-1 - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Machinery</subject><subject>Machinery and equipment</subject><subject>Male</subject><subject>Markers</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>Nitrotyrosine</subject><subject>Oxidants - metabolism</subject><subject>Oxidative stress</subject><subject>Oxygenase</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Photoreceptors</subject><subject>Plasma</subject><subject>Retina</subject><subject>Retinal degeneration</subject><subject>Retinitis</subject><subject>Retinitis pigmentosa</subject><subject>Retinitis Pigmentosa - blood</subject><subject>Retinitis Pigmentosa - metabolism</subject><subject>Studies</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxides</subject><subject>Systemic diseases</subject><subject>Thiobarbituric acid</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QDguDFjEnz0fZmYVj8GFhY8Os2pMnpNEPb1CTV9d-bcbrLFBSkF6c5fc6b05c3y54TvCa0IG_3bvKD6tajG2CNccHynD7IzklF85XIMX148n6WPQlhjzGnpRCPs7OcYVHlJT3P_KaL4MEgNUTrbq1JdTVXFKKKU0B2QLEFpL5P4NKxnXrnE2_QCN6OLXjVobpzziDXoFFFC0MM6KeNLfIQ7WCjDWi0uz71XVBPs0eN6gI8m-tF9vX9uy9XH1fXNx-2V5vrlU67xRWoCiuqTYMZUVCzmnCa9taKF1w0JQNRay60UVBCIThn3BhBDWsEVJxwRi-yl0fdsXNBznYFSRjNCRVMlInYHgnj1F6O3vbK_5JOWfmn4fxOKh-t7kAqpSmGiugaBMsrXbKCE5NrqgogFA63Xc63TXUPRqd_Tb4sRJdfBtvKnfshaVHkWPAk8GoW8C45HeI_Vp6pnUpb2aFxSUz3Nmi5YUVJD0E4LLP-C5UeA73VKTCNTf3FwJvFQGIi3MadmkKQ28-f_p-9-bZkX5-wLagutsF1U8raEJYgO4LauxA8NPfOESwPeb9zQx7yLue8p7EXp67fD90FnP4GZjn9aQ</recordid><startdate>20130912</startdate><enddate>20130912</enddate><creator>Martínez-Fernández de la Cámara, Cristina</creator><creator>Salom, David</creator><creator>Sequedo, Ma Dolores</creator><creator>Hervás, David</creator><creator>Marín-Lambíes, Cristina</creator><creator>Aller, Elena</creator><creator>Jaijo, Teresa</creator><creator>Díaz-Llopis, Manuel</creator><creator>Millán, José María</creator><creator>Rodrigo, Regina</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130912</creationdate><title>Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa</title><author>Martínez-Fernández de la Cámara, Cristina ; Salom, David ; Sequedo, Ma Dolores ; Hervás, David ; Marín-Lambíes, Cristina ; Aller, Elena ; Jaijo, Teresa ; Díaz-Llopis, Manuel ; Millán, José María ; Rodrigo, Regina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ea90a3cdf041aeb4b153240ca5756f84e6bc56cdae8e765545dd63d4f6e951543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Antioxidants</topic><topic>Antioxidants (Nutrients)</topic><topic>Antioxidants - metabolism</topic><topic>Apoptosis</topic><topic>Aqueous Humor - metabolism</topic><topic>Biomarkers</topic><topic>Blindness</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Case-Control Studies</topic><topic>Cluster Analysis</topic><topic>Consumption</topic><topic>Covariance</topic><topic>Cyclic GMP</topic><topic>Cyclic GMP - metabolism</topic><topic>Degeneration</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Heme</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Machinery</topic><topic>Machinery and equipment</topic><topic>Male</topic><topic>Markers</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric-oxide synthase</topic><topic>Nitrotyrosine</topic><topic>Oxidants - metabolism</topic><topic>Oxidative stress</topic><topic>Oxygenase</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Photoreceptors</topic><topic>Plasma</topic><topic>Retina</topic><topic>Retinal degeneration</topic><topic>Retinitis</topic><topic>Retinitis pigmentosa</topic><topic>Retinitis Pigmentosa - blood</topic><topic>Retinitis Pigmentosa - metabolism</topic><topic>Studies</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxides</topic><topic>Systemic diseases</topic><topic>Thiobarbituric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez-Fernández de la Cámara, Cristina</creatorcontrib><creatorcontrib>Salom, David</creatorcontrib><creatorcontrib>Sequedo, Ma Dolores</creatorcontrib><creatorcontrib>Hervás, David</creatorcontrib><creatorcontrib>Marín-Lambíes, Cristina</creatorcontrib><creatorcontrib>Aller, Elena</creatorcontrib><creatorcontrib>Jaijo, Teresa</creatorcontrib><creatorcontrib>Díaz-Llopis, Manuel</creatorcontrib><creatorcontrib>Millán, José María</creatorcontrib><creatorcontrib>Rodrigo, Regina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez-Fernández de la Cámara, Cristina</au><au>Salom, David</au><au>Sequedo, Ma Dolores</au><au>Hervás, David</au><au>Marín-Lambíes, Cristina</au><au>Aller, Elena</au><au>Jaijo, Teresa</au><au>Díaz-Llopis, Manuel</au><au>Millán, José María</au><au>Rodrigo, Regina</au><au>Lewin, Alfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-09-12</date><risdate>2013</risdate><volume>8</volume><issue>9</issue><spage>e74223</spage><pages>e74223-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24069283</pmid><doi>10.1371/journal.pone.0074223</doi><tpages>e74223</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-09, Vol.8 (9), p.e74223 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1432136468 |
| source | PubMed Central Free; MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Adult Analysis Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Apoptosis Aqueous Humor - metabolism Biomarkers Blindness Blood Blood & organ donations Case-Control Studies Cluster Analysis Consumption Covariance Cyclic GMP Cyclic GMP - metabolism Degeneration Enzymes Female Gene Expression Heme Heme Oxygenase-1 - genetics Hospitals Humans Leukocytes, Mononuclear - metabolism Machinery Machinery and equipment Male Markers Medical research Metabolism Metabolites Metabolome Middle Aged Multivariate analysis Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase Nitrotyrosine Oxidants - metabolism Oxidative stress Oxygenase Pathogenesis Patients Peripheral blood Photoreceptors Plasma Retina Retinal degeneration Retinitis Retinitis pigmentosa Retinitis Pigmentosa - blood Retinitis Pigmentosa - metabolism Studies Superoxide dismutase Superoxide Dismutase - metabolism Superoxides Systemic diseases Thiobarbituric acid |
| title | Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T05%3A28%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20antioxidant-oxidant%20status%20in%20the%20aqueous%20humor%20and%20peripheral%20blood%20of%20patients%20with%20retinitis%20pigmentosa&rft.jtitle=PloS%20one&rft.au=Mart%C3%ADnez-Fern%C3%A1ndez%20de%20la%20C%C3%A1mara,%20Cristina&rft.date=2013-09-12&rft.volume=8&rft.issue=9&rft.spage=e74223&rft.pages=e74223-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0074223&rft_dat=%3Cgale_plos_%3EA478300744%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1432136468&rft_id=info:pmid/24069283&rft_galeid=A478300744&rft_doaj_id=oai_doaj_org_article_aac30e91cbe6429c84751d2c3a7e13e4&rfr_iscdi=true |