Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia

Administration of mesenchymal stromal cells (MSC) improves functional outcome in the SOD1G93A mouse model of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) as well as in models of other neurological disorders. We have now investigated the effect of the interaction between...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e72926-e72926
Hauptverfasser:	Sun, Hui, Bénardais, Karelle, Stanslowsky, Nancy, Thau-Habermann, Nadine, Hensel, Niko, Huang, Dongya, Claus, Peter, Dengler, Reinhard, Stangel, Martin, Petri, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Animal models Animals Apoptosis Apoptosis - drug effects Astrocytes Astrocytes - drug effects Astrocytes - metabolism Autoimmune diseases Cells, Cultured Chemokine CX3CL1 - metabolism Chemokines Ciliary neurotrophic factor Ciliary Neurotrophic Factor - metabolism Conditioning Culture Media, Conditioned - pharmacology CX3CR1 protein Cytokines Fractalkine Gene expression Genetic engineering Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factors - metabolism Glial cells Health aspects Humans Interleukin 6 Medical research Medical schools Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Mice Microglia Microglia - drug effects Microglia - metabolism Motor neurons Motor Neurons - drug effects Motor Neurons - metabolism Nervous system Nervous system diseases Neurological diseases Neurology Neuronal-glial interactions Neurons Neuroprotection Neurosciences Neurotoxicity Neurotrophic factors Nitric-oxide synthase Rodents Spinal cord Staurosporine Staurosporine - pharmacology Stem cells Stromal cells Studies Transgenic mice Tumor necrosis factor-α Vascular endothelial growth factor
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