Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress

Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, decreases ROS levels and participates in cell survival under oxidative stress conditions. SIRT1 modulates the transcription fact...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73875
Hauptverfasser:	Hori, Yusuke S, Kuno, Atsushi, Hosoda, Ryusuke, Horio, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging AMP-Activated Protein Kinases - metabolism Animals Antimycin A Antimycin A - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Cell death Cell Line Cell Proliferation Cell survival Deacetylation DNA binding proteins Enzyme Activation - drug effects Forkhead Box Protein O1 Forkhead Box Protein O3 Forkhead protein Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXO1 protein FOXO3 protein FOXO4 protein Gene Knockdown Techniques Heart failure Humans Hydrogen Peroxide - metabolism Hydrogen Peroxide - pharmacology Immunoglobulins Ionizing radiation Kinases Medicine Mice Mitochondria Modulators Muscular dystrophy Mutation NAD Niacinamide Nicotinamide Oxidative Stress Oxygen p53 Protein Pharmacology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Resveratrol Rodents siRNA SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Stilbenes - pharmacology Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Survival Transcription factors Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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