Gymnemic acids inhibit hyphal growth and virulence in Candida albicans

Candida albicans is an opportunistic and polymorphic fungal pathogen that causes mucosal, disseminated and invasive infections in humans. Transition from the yeast form to the hyphal form is one of the key virulence factors in C. albicans contributing to macrophage evasion, tissue invasion and biofi...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74189-e74189
Hauptverfasser:	Vediyappan, Govindsamy, Dumontet, Vincent, Pelissier, Franck, d'Enfert, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Biofilms Caenorhabditis elegans - drug effects Caenorhabditis elegans - microbiology Candida Candida albicans Candida albicans - drug effects Candida albicans - growth & development Candida albicans - pathogenicity Cell cycle Chemical Sciences Chromatography Conversion Diabetes mellitus Fungal infections Fungi Fungicides Genes Germination Growth Gymnema sylvestre Gymnema sylvestre - chemistry Health aspects Herbal medicine Humans Hyphae Hyphae - drug effects Hyphae - growth & development Hyphae - pathogenicity Hypothesis testing Inhibition Killing Kinases Leaves Macrophages Medicinal plants Morphogenesis Mucosa Natural products Nosocomial infections Opportunist infection Organic chemistry Physiology Plant Extracts - chemistry Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Spores, Fungal - drug effects Spores, Fungal - growth & development Spores, Fungal - pathogenicity Transcription factors Transplants & implants Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Viability Virulence Virulence - drug effects Virulence factors Yeast
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