Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients

To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74724-e74724
Hauptverfasser:	Djukic, Tatjana I, Savic-Radojevic, Ana R, Pekmezovic, Tatjana D, Matic, Marija G, Pljesa-Ercegovac, Marija S, Coric, Vesna M, Radic, Tanja M, Suvakov, Sonja R, Krivic, Biljana N, Dragicevic, Dejan P, Simic, Tatjana P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Antineoplastic Agents - therapeutic use Biochemistry Bladder Bladder cancer Brain cancer Cancer Cancer patients Cancer research Cancer therapies Care and treatment Chemotherapy Deoxyribonucleic acid DNA Enzymes Female Gene expression Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genotype Genotypes Glutathione Glutathione transferase Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Health risks Humans Influence Invasiveness Male Medicine Middle Aged Mortality Muscles Neoplasm Invasiveness Patient outcomes Patients Pharmacogenetics Pharmacogenomics Pharmacology Polymorphism Polymorphism, Genetic Prognosis Proportional Hazards Models Survival Survival analysis Thiols Treatment Outcome Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urology
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