Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients
To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients...
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| creator | Djukic, Tatjana I Savic-Radojevic, Ana R Pekmezovic, Tatjana D Matic, Marija G Pljesa-Ercegovac, Marija S Coric, Vesna M Radic, Tanja M Suvakov, Sonja R Krivic, Biljana N Dragicevic, Dejan P Simic, Tatjana P |
| description | To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.
A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.
GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).
GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. |
| doi_str_mv | 10.1371/journal.pone.0074724 |
| format | Article |
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A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.
GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).
GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0074724</identifier><identifier>PMID: 24040330</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Analysis ; Antineoplastic Agents - therapeutic use ; Biochemistry ; Bladder ; Bladder cancer ; Brain cancer ; Cancer ; Cancer patients ; Cancer research ; Cancer therapies ; Care and treatment ; Chemotherapy ; Deoxyribonucleic acid ; DNA ; Enzymes ; Female ; Gene expression ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Genotypes ; Glutathione ; Glutathione transferase ; Glutathione Transferase - genetics ; GSTM1 protein ; GSTT1 protein ; Health risks ; Humans ; Influence ; Invasiveness ; Male ; Medicine ; Middle Aged ; Mortality ; Muscles ; Neoplasm Invasiveness ; Patient outcomes ; Patients ; Pharmacogenetics ; Pharmacogenomics ; Pharmacology ; Polymorphism ; Polymorphism, Genetic ; Prognosis ; Proportional Hazards Models ; Survival ; Survival analysis ; Thiols ; Treatment Outcome ; Tumors ; Urinary bladder ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - mortality ; Urology</subject><ispartof>PloS one, 2013-09, Vol.8 (9), p.e74724-e74724</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Djukic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Djukic et al 2013 Djukic et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e1ad96f2332443ba3c902d317a257dbb7d1b3aa1ed9d03e4230d596c8b44dc193</citedby><cites>FETCH-LOGICAL-c692t-e1ad96f2332443ba3c902d317a257dbb7d1b3aa1ed9d03e4230d596c8b44dc193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770566/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770566/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24040330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Djukic, Tatjana I</creatorcontrib><creatorcontrib>Savic-Radojevic, Ana R</creatorcontrib><creatorcontrib>Pekmezovic, Tatjana D</creatorcontrib><creatorcontrib>Matic, Marija G</creatorcontrib><creatorcontrib>Pljesa-Ercegovac, Marija S</creatorcontrib><creatorcontrib>Coric, Vesna M</creatorcontrib><creatorcontrib>Radic, Tanja M</creatorcontrib><creatorcontrib>Suvakov, Sonja R</creatorcontrib><creatorcontrib>Krivic, Biljana N</creatorcontrib><creatorcontrib>Dragicevic, Dejan P</creatorcontrib><creatorcontrib>Simic, Tatjana P</creatorcontrib><title>Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.
A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.
GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).
GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.</description><subject>Aged</subject><subject>Analysis</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biochemistry</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Brain cancer</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Glutathione</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>GSTM1 protein</subject><subject>GSTT1 protein</subject><subject>Health risks</subject><subject>Humans</subject><subject>Influence</subject><subject>Invasiveness</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Muscles</subject><subject>Neoplasm Invasiveness</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pharmacogenetics</subject><subject>Pharmacogenomics</subject><subject>Pharmacology</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Thiols</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Urinary bladder</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - 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therapeutic use</topic><topic>Biochemistry</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Brain cancer</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Glutathione</topic><topic>Glutathione transferase</topic><topic>Glutathione Transferase - genetics</topic><topic>GSTM1 protein</topic><topic>GSTT1 protein</topic><topic>Health risks</topic><topic>Humans</topic><topic>Influence</topic><topic>Invasiveness</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Muscles</topic><topic>Neoplasm Invasiveness</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pharmacogenetics</topic><topic>Pharmacogenomics</topic><topic>Pharmacology</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Thiols</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Urinary bladder</topic><topic>Urinary Bladder Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djukic, Tatjana I</au><au>Savic-Radojevic, Ana R</au><au>Pekmezovic, Tatjana D</au><au>Matic, Marija G</au><au>Pljesa-Ercegovac, Marija S</au><au>Coric, Vesna M</au><au>Radic, Tanja M</au><au>Suvakov, Sonja R</au><au>Krivic, Biljana N</au><au>Dragicevic, Dejan P</au><au>Simic, Tatjana P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-09-11</date><risdate>2013</risdate><volume>8</volume><issue>9</issue><spage>e74724</spage><epage>e74724</epage><pages>e74724-e74724</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.
A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.
GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).
GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24040330</pmid><doi>10.1371/journal.pone.0074724</doi><tpages>e74724</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1431991490 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Analysis Antineoplastic Agents - therapeutic use Biochemistry Bladder Bladder cancer Brain cancer Cancer Cancer patients Cancer research Cancer therapies Care and treatment Chemotherapy Deoxyribonucleic acid DNA Enzymes Female Gene expression Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genotype Genotypes Glutathione Glutathione transferase Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Health risks Humans Influence Invasiveness Male Medicine Middle Aged Mortality Muscles Neoplasm Invasiveness Patient outcomes Patients Pharmacogenetics Pharmacogenomics Pharmacology Polymorphism Polymorphism, Genetic Prognosis Proportional Hazards Models Survival Survival analysis Thiols Treatment Outcome Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urology |
| title | Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T23%3A53%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutathione%20S-transferase%20T1,%20O1%20and%20O2%20polymorphisms%20are%20associated%20with%20survival%20in%20muscle%20invasive%20bladder%20cancer%20patients&rft.jtitle=PloS%20one&rft.au=Djukic,%20Tatjana%20I&rft.date=2013-09-11&rft.volume=8&rft.issue=9&rft.spage=e74724&rft.epage=e74724&rft.pages=e74724-e74724&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0074724&rft_dat=%3Cgale_plos_%3EA478321149%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1431991490&rft_id=info:pmid/24040330&rft_galeid=A478321149&rft_doaj_id=oai_doaj_org_article_5dccdb0c349249b1a6ea88348bc251ce&rfr_iscdi=true |