Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells

Green barley extract (GB) was investigated for possible anti-cancer activity by examining its anti-proliferative and pro-apoptotic properties on human leukemia/lymphoma cell lines. Our results indicate that GB exhibits selective anti-proliferative activity on a panel of leukemia/lymphoma cells in co...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73508
Hauptverfasser:	Robles-Escajeda, Elisa, Lerma, Dennise, Nyakeriga, Alice M, Ross, Jeremy A, Kirken, Robert A, Aguilera, Renato J, Varela-Ramirez, Armando
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Analysis Anticancer properties Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antiproliferatives Apoptosis Apoptosis - drug effects Barley Biocompatibility Biomedical research Biotechnology Cancer Cancer treatment Caspase 3 - metabolism Caspase inhibitors Caspase-3 Caspase-8 Cell cycle Cell Cycle - drug effects Cell death Cell Line, Tumor Cell Proliferation - drug effects Cleavage Cytoplasmic membranes Cytotoxicity Deoxyribonucleic acid Depolarization Dietary supplements DNA DNA fragmentation DNA Fragmentation - drug effects Flavonoids Fragmentation Hordeum - chemistry Humans Intracellular signalling Kinases Lck protein Leukemia Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Lymphatic leukemia Lymphocytes B Lymphoma Lymphoma - drug therapy Lymphoma - metabolism Lymphoma - pathology Mitochondria Phosphatidylserine Plant Extracts - chemistry Plant Extracts - pharmacology Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism Studies Toxicity Translocation Tumor cell lines Tumor necrosis factor-TNF Tumor necrosis factor-α Tyrosine
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