Multicenter intestinal current measurements in rectal biopsies from CF and non-CF subjects to monitor CFTR function

Intestinal current measurements (ICM) from rectal biopsies are a sensitive means to detect cystic fibrosis transmembrane conductance regulator (CFTR) function, but have not been optimized for multicenter use. We piloted multicenter standard operating procedures (SOPs) to detect CFTR activity by ICM...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73905-e73905
Hauptverfasser:	Clancy, John P, Szczesniak, Rhonda D, Ashlock, Melissa A, Ernst, Sarah E, Fan, Lijuan, Hornick, Douglas B, Karp, Philip H, Khan, Umer, Lymp, James, Ostmann, Alicia J, Rezayat, Amir, Starner, Timothy D, Sugandha, Shajan P, Sun, Hongtao, Quinney, Nancy, Donaldson, Scott H, Rowe, Steven M, Gabriel, Sherif E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Bioassays Biological activity Biomarkers Biopsy Bumetanide Carbachol Chlorides - metabolism Clinical trials Cold effects Cold storage Conductance Confidence intervals Correlation Correlation coefficient Correlation coefficients Cyclic AMP - metabolism Cystic fibrosis Cystic Fibrosis - diagnosis Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Female Forskolin Hospitals Humans Internal medicine Intestine Ion transport Male Medical instruments Medical research Medicine Middle Aged Mutation Pediatrics Proteins Rectum Rectum - metabolism Rectum - pathology ROC Curve Rodents Sodium - metabolism Storage Studies Suction Young Adult
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