The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance

Taste sensitivity to PROP varies greatly among individuals and is associated with polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform papilla density on the anterior tongue surface. Recently we showed that the PROP non-taster phenotype is strongly associated with the...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74151
Hauptverfasser:	Melis, Melania, Atzori, Elena, Cabras, Stefano, Zonza, Andrea, Calò, Carla, Muroni, Patrizia, Nieddu, Mariella, Padiglia, Alessandra, Sogos, Valeria, Tepper, Beverly J, Tomassini Barbarossa, Iole
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Binding sites Bitter taste Bitterness Carbonic Anhydrases - genetics Cell Line Cell Proliferation Cytology Density Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Gene polymorphism Genomes Genotype Genotypes Goats Haplotypes Humans Male Morphology Mouth Mucosa - cytology Mouth Mucosa - drug effects Mouth Mucosa - metabolism Mutation Papillae Papillae (fungiform) Phenotype Point mutation Polymorphism Polymorphism, Single Nucleotide Propylthiouracil - pharmacology Protein Isoforms - genetics Proteins Receptors, G-Protein-Coupled - genetics Saliva Saliva - chemistry Scaling Sensitivity Sensitivity analysis Studies Taste Taste - drug effects Taste - genetics Taste Buds - cytology Taste Buds - drug effects Taste Buds - metabolism Taste receptors Taste Threshold - drug effects Taste Threshold - genetics Taste thresholds Tongue
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