Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects

Before the advent of genome-wide association studies (GWAS), ADAM33, ADRB2, CD14, MS4A2 (alias FCER1B), IL13, IL4, IL4R, and TNF constituted the most replicated non-HLA candidate genes with asthma and related traits. However, except for the IL13-IL4 region, none of these genes have been found in clo...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73157
Hauptverfasser:	Pino-Yanes, María, Corrales, Almudena, Cumplido, José, Poza, Paloma, Sánchez-Machín, Inmaculada, Sánchez-Palacios, Anselmo, Figueroa, Javier, Acosta-Fernández, Orlando, Buset, Nisa, García-Robaina, José Carlos, Hernández, Mariano, Villar, Jesús, Carrillo, Teresa, Flores, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics Adolescent Adult Age Age factors Alleles Allergies Asthma Asthma - diagnosis Asthma - genetics Atopy Case-Control Studies CD14 antigen Child Chromosome Mapping Diagnosis Disease susceptibility Gene Frequency Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetics Genome-wide association studies Genomes Genomics Genotype Hospitals Humans Interleukin 1 Interleukin 13 Interleukin 4 Interleukin 4 receptors Interleukin-4 Receptor alpha Subunit - genetics Laboratories Medical diagnosis Odds Ratio Polymorphism, Single Nucleotide Receptors, IgE - genetics Reproducibility Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Tumor necrosis factor Tumor necrosis factor-TNF Young Adult
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