The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome
Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (S...
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| description | Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma mtDNA levels are associated with injury severity and cloud predict post-traumatic SIRS in patients with acute traumatic injury.
Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population's clinical and laboratory data were analyzed.
The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P |
| doi_str_mv | 10.1371/journal.pone.0072834 |
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Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population's clinical and laboratory data were analyzed.
The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P<0.001) and was independently correlated with the ISS score (r=0.287, P<0.001). The plasma mtDNA concentration was also significantly higher in patients who developed post-traumatic SIRS than in patients who did not (1774.03 (564.870-10901.3)pg/ml vs 500.496 (145.415-1285.60)pg/ml, P<0.001). Multiple logistic regression analysis revealed that the plasma mtDNA was an independent predictors for post-traumatic SIRS (OR, 1.183 (95%CI, 1.015-1.379), P=0.032). Further ROC analysis demonstrated that a high plasma mtDNA level predicted post-traumatic SIRS with a sensitivity of 67% and a specificity of 76%, with a cut-off value of 1.3185 µg/ml being established, and the area under the ROC curves (AUC) was 0.725 (95% CI 0.613-0.837).
Plasma mtDNA was an independent indictor with moderate discriminative power to predict the risk of post-traumatic SIRS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0072834</identifier><identifier>PMID: 23977360</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Biomarkers ; Blood ; C-Reactive Protein - metabolism ; Cancer ; Case-Control Studies ; Complications ; Damage detection ; Damage patterns ; Data processing ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA, Mitochondrial - blood ; Drug overdose ; Emergency medical care ; Female ; Health care ; Hospitals ; Humans ; Inflammation ; Inflammatory response ; Injuries ; Laboratories ; Leukocyte Count ; Logistic Models ; Male ; Medical research ; Medicine ; Middle Aged ; Mitochondrial DNA ; ND2 gene ; Neutrophils ; Patients ; Plasma ; Population studies ; Predictive Value of Tests ; Regression analysis ; ROC Curve ; Sepsis ; Severity of Illness Index ; Stroke ; Studies ; Systemic inflammatory response syndrome ; Systemic Inflammatory Response Syndrome - blood ; Systemic Inflammatory Response Syndrome - etiology ; Trauma ; Wounds and Injuries - blood ; Wounds and Injuries - complications ; Young Adult</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e72834-e72834</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Gu et al 2013 Gu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-cc63951d96adfb76e8122428261207ceb321b4c73efd25decaa3a698e27809293</citedby><cites>FETCH-LOGICAL-c743t-cc63951d96adfb76e8122428261207ceb321b4c73efd25decaa3a698e27809293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748121/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748121/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23977360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stover, Cordula M.</contributor><creatorcontrib>Gu, Xiaoling</creatorcontrib><creatorcontrib>Yao, Yanwen</creatorcontrib><creatorcontrib>Wu, Guannan</creatorcontrib><creatorcontrib>Lv, Tangfeng</creatorcontrib><creatorcontrib>Luo, Liang</creatorcontrib><creatorcontrib>Song, Yong</creatorcontrib><title>The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma mtDNA levels are associated with injury severity and cloud predict post-traumatic SIRS in patients with acute traumatic injury.
Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population's clinical and laboratory data were analyzed.
The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P<0.001) and was independently correlated with the ISS score (r=0.287, P<0.001). The plasma mtDNA concentration was also significantly higher in patients who developed post-traumatic SIRS than in patients who did not (1774.03 (564.870-10901.3)pg/ml vs 500.496 (145.415-1285.60)pg/ml, P<0.001). Multiple logistic regression analysis revealed that the plasma mtDNA was an independent predictors for post-traumatic SIRS (OR, 1.183 (95%CI, 1.015-1.379), P=0.032). Further ROC analysis demonstrated that a high plasma mtDNA level predicted post-traumatic SIRS with a sensitivity of 67% and a specificity of 76%, with a cut-off value of 1.3185 µg/ml being established, and the area under the ROC curves (AUC) was 0.725 (95% CI 0.613-0.837).
Plasma mtDNA was an independent indictor with moderate discriminative power to predict the risk of post-traumatic SIRS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Complications</subject><subject>Damage detection</subject><subject>Damage patterns</subject><subject>Data processing</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA, Mitochondrial - blood</subject><subject>Drug overdose</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>Health care</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Injuries</subject><subject>Laboratories</subject><subject>Leukocyte Count</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mitochondrial DNA</subject><subject>ND2 gene</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Plasma</subject><subject>Population studies</subject><subject>Predictive Value of Tests</subject><subject>Regression analysis</subject><subject>ROC Curve</subject><subject>Sepsis</subject><subject>Severity of Illness Index</subject><subject>Stroke</subject><subject>Studies</subject><subject>Systemic inflammatory response syndrome</subject><subject>Systemic Inflammatory Response Syndrome - blood</subject><subject>Systemic Inflammatory Response Syndrome - etiology</subject><subject>Trauma</subject><subject>Wounds and Injuries - blood</subject><subject>Wounds and Injuries - complications</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk22L1DAQx4so3nn6DUQLguiLXfPQTdo3wnI-LRwe6OnbME3S3Rxt00tScb-9s27v2JV7IaFpmPzmn8xMJsueUzKnXNJ3134MPbTzwfd2TohkJS8eZKe04mwmGOEPD9Yn2ZMYrwlZ8FKIx9kJ45WUXJDTLF5tbD60EDvIO5e83vjeBAdt_uHrMncxhz53vbGDxalP-RCscTr5kDf4DT6mWQowdpCczuM2JtvhwvVNCx0afdjmwUa8Y7S4jdK-s0-zRw200T6b_mfZj08fr86_zC4uP6_OlxczLQueZloLXi2oqQSYppbClpSxgpVMUEaktjVntC605LYxbGGsBuAgqtIyWZKKVfwse7nXHVof1ZSvqGjBiSwlJhGJ1Z4wHq7VEFwHYas8OPXX4MNaQcDIWqvqCmTVCE7MoigASL2ogVLOhRSmtqZBrffTaWPdWaMxWwHaI9Hjnd5t1Nr_UlwWGBlFgTeTQPA3o41JdS5q27bQWz_u7o2xSyRLRF_9g94f3UStAQPAmng8V-9E1bKQJSNFIRhS83soHGZXSnxcjUP7kcPbIwdkkv2d1jDGqFbfv_0_e_nzmH19wG4stGkTfTsmh6_nGCz2oA4-xmCbuyRTona9cZsNtesNNfUGur04LNCd020z8D9O1gsj</recordid><startdate>20130820</startdate><enddate>20130820</enddate><creator>Gu, Xiaoling</creator><creator>Yao, Yanwen</creator><creator>Wu, Guannan</creator><creator>Lv, Tangfeng</creator><creator>Luo, Liang</creator><creator>Song, Yong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130820</creationdate><title>The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome</title><author>Gu, Xiaoling ; Yao, Yanwen ; Wu, Guannan ; Lv, Tangfeng ; Luo, Liang ; Song, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-cc63951d96adfb76e8122428261207ceb321b4c73efd25decaa3a698e27809293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Complications</topic><topic>Damage detection</topic><topic>Damage patterns</topic><topic>Data processing</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA, Mitochondrial - blood</topic><topic>Drug overdose</topic><topic>Emergency medical care</topic><topic>Female</topic><topic>Health care</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Injuries</topic><topic>Laboratories</topic><topic>Leukocyte Count</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mitochondrial DNA</topic><topic>ND2 gene</topic><topic>Neutrophils</topic><topic>Patients</topic><topic>Plasma</topic><topic>Population studies</topic><topic>Predictive Value of Tests</topic><topic>Regression analysis</topic><topic>ROC Curve</topic><topic>Sepsis</topic><topic>Severity of Illness Index</topic><topic>Stroke</topic><topic>Studies</topic><topic>Systemic inflammatory response syndrome</topic><topic>Systemic Inflammatory Response Syndrome - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Xiaoling</au><au>Yao, Yanwen</au><au>Wu, Guannan</au><au>Lv, Tangfeng</au><au>Luo, Liang</au><au>Song, Yong</au><au>Stover, Cordula M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-20</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e72834</spage><epage>e72834</epage><pages>e72834-e72834</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma mtDNA levels are associated with injury severity and cloud predict post-traumatic SIRS in patients with acute traumatic injury.
Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population's clinical and laboratory data were analyzed.
The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P<0.001) and was independently correlated with the ISS score (r=0.287, P<0.001). The plasma mtDNA concentration was also significantly higher in patients who developed post-traumatic SIRS than in patients who did not (1774.03 (564.870-10901.3)pg/ml vs 500.496 (145.415-1285.60)pg/ml, P<0.001). Multiple logistic regression analysis revealed that the plasma mtDNA was an independent predictors for post-traumatic SIRS (OR, 1.183 (95%CI, 1.015-1.379), P=0.032). Further ROC analysis demonstrated that a high plasma mtDNA level predicted post-traumatic SIRS with a sensitivity of 67% and a specificity of 76%, with a cut-off value of 1.3185 µg/ml being established, and the area under the ROC curves (AUC) was 0.725 (95% CI 0.613-0.837).
Plasma mtDNA was an independent indictor with moderate discriminative power to predict the risk of post-traumatic SIRS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23977360</pmid><doi>10.1371/journal.pone.0072834</doi><tpages>e72834</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-08, Vol.8 (8), p.e72834-e72834 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Aged, 80 and over Analysis Biomarkers Blood C-Reactive Protein - metabolism Cancer Case-Control Studies Complications Damage detection Damage patterns Data processing Deoxyribonucleic acid DNA DNA methylation DNA, Mitochondrial - blood Drug overdose Emergency medical care Female Health care Hospitals Humans Inflammation Inflammatory response Injuries Laboratories Leukocyte Count Logistic Models Male Medical research Medicine Middle Aged Mitochondrial DNA ND2 gene Neutrophils Patients Plasma Population studies Predictive Value of Tests Regression analysis ROC Curve Sepsis Severity of Illness Index Stroke Studies Systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - etiology Trauma Wounds and Injuries - blood Wounds and Injuries - complications Young Adult |
| title | The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A06%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20plasma%20mitochondrial%20DNA%20is%20an%20independent%20predictor%20for%20post-traumatic%20systemic%20inflammatory%20response%20syndrome&rft.jtitle=PloS%20one&rft.au=Gu,%20Xiaoling&rft.date=2013-08-20&rft.volume=8&rft.issue=8&rft.spage=e72834&rft.epage=e72834&rft.pages=e72834-e72834&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0072834&rft_dat=%3Cgale_plos_%3EA478204462%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1430787137&rft_id=info:pmid/23977360&rft_galeid=A478204462&rft_doaj_id=oai_doaj_org_article_b9a79f630d544aa0b5ba1133676dbedf&rfr_iscdi=true |