Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis

MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic small non-coding RNAs (sRNAs). Our model uses a...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72676-e72676
Hauptverfasser:	Noorbakhsh, Javad, Lang, Alex H, Mehta, Pankaj
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology Catalysis Cell cycle Cell division Computer applications Computer Simulation Crosstalk E coli Escherichia coli Gene expression Gene Expression Regulation - physiology Gene regulation Genes Genetic research Growth rate Hepatitis Hypotheses Messenger RNA MicroRNA MicroRNAs MicroRNAs - physiology miRNA Models, Theoretical Molecular chains Molecular machines mRNA Noise Noise measurement Noise sensitivity Physics Prokaryotes Proteins Ribonucleic acid RNA RNA - genetics
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