HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women

As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, w...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71040-e71040
Hauptverfasser:	Li, Dalin, Fu, Zhenkun, Chen, Shuang, Yuan, Weiguang, Liu, Yanhong, Li, Liqun, Pang, Da, Li, Dianjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Alleles Analysis Asian Continental Ancestry Group Biology Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - ethnology Breast Neoplasms - genetics Cancer Cancer genetics Cancer metastasis Cancer research Cancer therapies Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - ethnology Carcinoma, Ductal, Breast - genetics Case-Control Studies Deoxyribonucleic acid Development and progression Disease prevention DNA DNA Mutational Analysis Estrogens Female Females Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotypes Haplotypes Health risks Hospitals Humans Immunity Immunology Infections Inflammatory diseases Laboratories Lymph nodes Lymphatic Metastasis Lymphocytes Lymphocytes T Medical prognosis Medicine Metastases Middle Aged p53 Protein Pathogenesis Polymerase chain reaction Polymorphism, Genetic Precision medicine Progesterone Proteins Receptors, Estrogen - genetics Receptors, Progesterone - genetics Receptors, Tumor Necrosis Factor, Member 14 - genetics Restriction fragment length polymorphism Signal transduction Single-nucleotide polymorphism Surgery T cells Tumor necrosis factor-TNF Tumor proteins Tumor Suppressor Protein p53 - genetics Tumors
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Zusammenfassung:	As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0071040