An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk

Selective estrogen receptor modulators (SERMs) are effective therapeutics that preserve favorable actions of estrogens on bone and act as antiestrogens in breast tissue, decreasing the risk of vertebral fractures and breast cancer, but their potential in neuroprotective and procognitive therapy is l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70740
Hauptverfasser:	VandeVrede, Lawren, Abdelhamid, Ramy, Qin, Zhihui, Choi, Jaewoo, Piyankarage, Sujeewa, Luo, Jia, Larson, John, Bennett, Brian M, Thatcher, Gregory R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Anticoagulants Anticoagulants - pharmacology Antiestrogens Aorta Biology Breast cancer Cell Hypoxia Chemistry Cognition Cognitive ability Denudation Deprivation Endothelium Estrogen antagonists Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Fractures G protein-coupled receptors Genetic engineering Glucose - deficiency Health risks Hippocampus Hormone replacement therapy Long-term potentiation Male Medicine Memory Memory - drug effects Mice Modulators Neurodegenerative diseases Neuromodulation Neurons - cytology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Nootropic Agents - pharmacology Oxygen Pharmacology Phenols (Class of compounds) Piperidines - pharmacology Primary Cell Culture Rats Receptors Receptors, Estrogen Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Restoration Risk RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Selective estrogen receptor modulators Selective Estrogen Receptor Modulators - pharmacology Therapy Thiophenes - pharmacology Transgenic mice Vasodilation Vasodilation - drug effects Vasodilator agents Vertebrae Xenoestrogens
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!