Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applica...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71345-e71345
Hauptverfasser:	Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, White, Jon, Giambartolomei, Claudia, McLachlan, Stela, Zabaneh, Delilah, Cavadino, Alana, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom, Holmes, Michael V, Warren, Helen, Swerdlow, Daniel I, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Sofat, Reecha, Caulfield, Mark, Ebrahim, Shah, Lawlor, Debbie A, Talmud, Philippa J, Humphries, Steve E, Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Day, Ian N, Whincup, Peter, Morris, Richard, Strachan, Mark W J, Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Dudbridge, Frank, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging Bioindicators Biology Biomarkers Cardiovascular disease Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Childrens health Cohort analysis Consortia Epidemiology Evolution Female Genetic aspects Genetic Association Studies Genetic diversity Genetic Markers Genetic variance Genetics Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics Health care Health policy Health sciences Heart Hospitals Humans Hygiene Laboratories Longitudinal Studies Male Medical research Medical schools Medicine Metabolic Networks and Pathways - genetics Metabolism Metabolites Metagenomics Middle Aged Oligonucleotide Array Sequence Analysis Polymorphism Polymorphism, Single Nucleotide Population Population studies Public health Research Design Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Type 2 diabetes Womens health
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