Seeded fibrillation as molecular basis of the species barrier in human prion diseases

Prion diseases are transmissible spongiform encephalopathies in humans and animals, including scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer, and Creutzfeldt-Jakob disease (CJD) in humans. The hallmark of prion diseases is the conversion of...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72623-e72623
Hauptverfasser:	Luers, Lars, Bannach, Oliver, Stöhr, Jan, Wördehoff, Michael Marius, Wolff, Martin, Nagel-Steger, Luitgard, Riesner, Detlev, Willbold, Dieter, Birkmann, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - metabolism Animals Bioassays Biology Bovine spongiform encephalopathy BSE Cattle Chronic wasting disease Circular Dichroism Coding Creutzfeldt-Jakob disease Deer Disease transmission Diseases Encephalopathy Epidemiology Fibrillation Food contamination & poisoning Homology Humans Kinetics Medicine Ovis aries Prion Diseases - metabolism Prion Diseases - pathology Prion protein Prions Proteins PrPSc Proteins - metabolism Scrapie Seeding Seeds Sheep Species Species Specificity Substrates Thiazoles - metabolism Transgenic animals Transmissible spongiform encephalopathy Ultracentrifugation Veterinary Science
Online-Zugang:	Volltext
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