Ethnic variation in inflammatory profile in tuberculosis

Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inf...

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Veröffentlicht in:	PLoS pathogens 2013-07, Vol.9 (7), p.e1003468
Hauptverfasser:	Coussens, Anna K, Wilkinson, Robert J, Nikolayevskyy, Vladyslav, Elkington, Paul T, Hanifa, Yasmeen, Islam, Kamrul, Timms, Peter M, Bothamley, Graham H, Claxton, Alleyna P, Packe, Geoffrey E, Darmalingam, Mathina, Davidson, Robert N, Milburn, Heather J, Baker, Lucy V, Barker, Richard D, Drobniewski, Francis A, Mein, Charles A, Bhaw-Rosun, Leena, Nuamah, Rosamond A, Griffiths, Christopher J, Martineau, Adrian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics, Antitubercular - therapeutic use Antigens, Bacterial - metabolism Asians Bacterial Load - drug effects Biology Biomarkers Blacks Blood Cells - immunology Blood Cells - metabolism Cells, Cultured Cultural differences Female Genealogy Genetic aspects Genetic variation Genotype & phenotype Hematology Host-parasite relationships Host-Pathogen Interactions - drug effects Humans Inflammation Mediators - blood Inflammation Mediators - metabolism Isoniazid - therapeutic use London Male Medicine Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Phylogenetics Phylogeny Physiological aspects Sputum - drug effects Sputum - microbiology Studies Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - virology Whites Young Adult
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