Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells

The factors determining the functional avidity and its relationship with the broad heterogeneity of antiviral T cell responses remain partially understood. We investigated HIV-specific CD8 T cell responses in 85 patients with primary HIV infection (PHI) or chronic (progressive and non-progressive) i...

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Veröffentlicht in:	PLoS pathogens 2013-07, Vol.9 (7), p.e1003423
Hauptverfasser:	Viganò, Selena, Bellutti Enders, Felicitas, Miconnet, Isabelle, Cellerai, Cristina, Savoye, Anne-Laure, Rozot, Virginie, Perreau, Matthieu, Faouzi, Mohamed, Ohmiti, Khalid, Cavassini, Matthias, Bart, Pierre-Alexandre, Pantaleo, Giuseppe, Harari, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - therapeutic use Antibodies, Viral - analysis Antibody Affinity Biology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Chronic Disease Cohort Studies Cross-Sectional Studies Cyclosporine - therapeutic use Disease Progression Drug therapy Epitope Mapping Health aspects HIV HIV (Viruses) HIV - drug effects HIV - growth & development HIV - immunology HIV - isolation & purification HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Humans Immunity, Cellular - drug effects Immunology Immunosuppressive Agents - therapeutic use Infections Longitudinal Studies Medicine Physiological aspects Receptors, Antigen, T-Cell - biosynthesis Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism T cell receptors T cells Up-Regulation - drug effects Viremia Viremia - blood Viremia - drug therapy Viremia - immunology Viremia - virology Virulence (Microbiology) Virus Replication - drug effects
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