Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice

Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71361
Hauptverfasser:	Sáez, Pablo J, Orellana, Juan A, Vega-Riveros, Natalia, Figueroa, Vania A, Hernández, Diego E, Castro, Juan F, Klein, Andrés D, Jiang, Jean X, Zanlungo, Silvana, Sáez, Juan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Animals Animals, Newborn Antibodies - pharmacology Apoptosis Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biology Brain Brain diseases Calcium (intracellular) Calcium - metabolism Calcium Signaling Calcium signalling Cell Communication - drug effects Cell signaling Cells, Cultured Channels Cholesterol Communication Connexin 43 Connexin 43 - antagonists & inhibitors Connexin 43 - genetics Connexin 43 - metabolism Connexins - genetics Connexins - metabolism Cortex Disease Disease Models, Animal Gap junctions Gap Junctions - drug effects Gap Junctions - metabolism Gene Deletion Gene expression Gene Expression Regulation Genetic disorders Hippocampus Hippocampus - drug effects Hippocampus - metabolism Homeostasis Inflammation Intracellular Intracellular Signaling Peptides and Proteins Intracellular signalling Laboratory animals Lipids Medicine Metabolic disorders Mice Mice, Knockout Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Neurodegenerative diseases Niemann-Pick disease Niemann-Pick Disease, Type C - metabolism Niemann-Pick Disease, Type C - pathology Npc1 protein Oscillations Proteins Proteins - genetics Proteins - metabolism Receptors Receptors, Purinergic P2Y1 - genetics Receptors, Purinergic P2Y1 - metabolism Rodents Tissue Culture Techniques
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