Quality score based identification and correction of pyrosequencing errors

Massively-parallel DNA sequencing using the 454/pyrosequencing platform allows in-depth probing of diverse sequence populations, such as within an HIV-1 infected individual. Analysis of this sequence data, however, remains challenging due to the shorter read lengths relative to that obtained by Sang...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73015-e73015
Hauptverfasser:	Iyer, Shyamala, Bouzek, Heather, Deng, Wenjie, Larsen, Brendan, Casey, Eleanor, Mullins, James I
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Bioinformatics Computational Biology - methods Computer simulation Datasets Deoxyribonucleic acid DNA DNA sequencing Drug resistance Error correction Error correction & detection Error detection Gene mapping Gene sequencing Genome, Viral Genomes Genomics High-Throughput Nucleotide Sequencing - methods High-Throughput Nucleotide Sequencing - standards HIV HIV-1 - genetics Human immunodeficiency virus Humans Identification methods Insertion Methods Mutation Nucleotide sequencing Polymorphism, Single Nucleotide Population genetics Populations Quality Quality Control Reduction Sensitivity Sensitivity and Specificity Sequence Analysis, DNA - methods Single-nucleotide polymorphism
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