Microarray profiling of mononuclear peripheral blood cells identifies novel candidate genes related to chemoradiation response in rectal cancer

Preoperative chemoradiation significantly improves oncological outcome in locally advanced rectal cancer. However there is no effective method of predicting tumor response to chemoradiation in these patients. Peripheral blood mononuclear cells have emerged recently as pathology markers of cancer and...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74034
Hauptverfasser:	Palma, Pablo, Cuadros, Marta, Conde-Muíño, Raquel, Olmedo, Carmen, Cano, Carlos, Segura-Jiménez, Inmaculada, Blanco, Armando, Bueno, Pablo, Ferrón, J Antonio, Medina, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Adult Aged Analysis Apoptosis Artificial intelligence Biochemistry Biomarkers, Tumor Blood Blood cells Cancer Cancer genetics Cancer therapies Chemoradiotherapy Chemotherapy Colon Colorectal cancer Computer science DNA microarrays Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects Genes Histocompatibility antigen HLA Humans Hybridization Immune response Immune system Immunology Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - radiation effects Male Medical research Middle Aged Molecular biology Neoplasm Staging Organs Patients Peripheral blood mononuclear cells Prognosis Quality Radiation therapy Rectal Neoplasms - drug therapy Rectal Neoplasms - genetics Rectal Neoplasms - radiotherapy Rectum Regression analysis Reproducibility of Results Ribonucleic acid RNA Statistical analysis Statistical methods Surgery Treatment Outcome Vascular endothelial growth factor
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