Toxoplasma gondii protein disulfide isomerase (TgPDI) is a novel vaccine candidate against toxoplasmosis

Toxoplasma gondii is a ubiquitous protozoan parasite that can infect all warm-blooded animals, including both mammals and birds. Protein disulfide isomerase (PDI) localises to the surface of T. gondii tachyzoites and modulates the interactions between parasite and host cells. In this study, the prot...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70884
Hauptverfasser:	Wang, Hai-Long, Li, Ya-Qing, Yin, Li-Tian, Meng, Xiao-Li, Guo, Min, Zhang, Jian-Hong, Liu, Hong-Li, Liu, Juan-Juan, Yin, Guo-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal tissues Animals Antibodies Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - genetics Antigens, Protozoan - immunology Antigens, Protozoan - isolation & purification Biology Birds Brain Conserved Sequence Cysts Cytokines E coli Escherichia coli Female Gene Expression Group dynamics Health aspects Homeotherms Immune response Immunity, Humoral Immunization Immunoglobulin G Infection Infections Interferon Interleukin 10 Interleukin 2 Interleukin 4 Laboratory animals Liver Lymphocyte Activation - immunology Lymphocyte Subsets - immunology Lymphocytes Male Medical research Medicine Mice Molecular Sequence Data Parasites Parasitology Physiology Protein disulfide-isomerase Protein Disulfide-Isomerases - chemistry Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - immunology Protein Disulfide-Isomerases - isolation & purification Proteins Proteomics Protozoa Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Proteins - isolation & purification Protozoan Vaccines - immunology Recombinant Proteins Rodents Sequence Alignment Survival Tachyzoites Toxoplasma - genetics Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis Toxoplasmosis, Animal - mortality Toxoplasmosis, Animal - prevention & control Vaccines Virulence (Microbiology) γ-Interferon
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