Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin's actions in nondiabetic and diabetic apolipoprotein E-null mice

Several recent reports have revealed that dipeptidyl peptidase (DPP)-4 inhibitors have suppressive effects on atherosclerosis in apolipoprotein E-null (Apoe (-/-)) mice. It remains to be seen, however, whether this effect stems from increased levels of the two active incretins, glucagon-like peptide...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70933-e70933
Hauptverfasser:	Terasaki, Michishige, Nagashima, Masaharu, Nohtomi, Kyoko, Kohashi, Kyoko, Tomoyasu, Masako, Sinmura, Kyoko, Nogi, Yukinori, Katayama, Yuki, Sato, Kengo, Itoh, Fumiko, Watanabe, Takuya, Hirano, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Age Alternative Splicing Animals Aorta Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Attenuation Biology Blood pressure Body weight Diabetes Diabetes mellitus Dipeptidyl Peptidase 4 - metabolism Dipeptidyl-peptidase IV Dipeptidyl-Peptidase IV Inhibitors - pharmacology Disease Models, Animal Drinking water Endocrinology Exudation Foam Cells - metabolism Foam Cells - pathology Foams Food intake Gene Expression Profiling Gene Expression Regulation Gene Order GIP protein Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide-1 Receptor Glucose Glucose Tolerance Test Hemoglobin Incretins - metabolism Incubation Inhibitors Laboratory animals Lesions Life sciences Macrophages Macrophages - metabolism Macrophages - pathology Male Medical research Medicine Metabolism Mice Mice, Inbred NOD Mice, Knockout Nitriles - pharmacology Peptidase Peritoneum Pharmacy Polypeptides Pyrrolidines - pharmacology Receptors, Glucagon - antagonists & inhibitors Receptors, Glucagon - genetics Receptors, Glucagon - metabolism Rodents Streptozocin Test animals
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