Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection

Enterohaemorrhagic E. coli (EHEC) induces actin reorganization of host cells by injecting various effectors into host cytosol through type III secretion systems. EspB is the natively partially folded EHEC effector which binds to host α-catenin to promote the actin bundling. However, its structural b...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71618-e71618
Hauptverfasser:	Hamaguchi, Mitsuhide, Kamikubo, Hironari, Suzuki, Kayo N, Hagihara, Yoshihisa, Yanagihara, Itaru, Sakata, Ikuhiro, Kataoka, Mikio, Hamada, Daizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Algorithms alpha Catenin - chemistry alpha Catenin - metabolism Amino Acid Sequence Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - metabolism Biochemistry Bioenergetics Bioinformatics Biology Biophysics Childrens health Chromatography Circular Dichroism Critical care Cytosol Denaturation Dichroism Dissection E coli Enterohemorrhagic Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Fragmentation Homology Laboratories Maternal & child health Medicine Molecular Sequence Data Peptides Physics Protein Binding Protein folding Protein Structure, Secondary Protein Unfolding Random coil Recognition Scattering, Small Angle Secretion Small angle X ray scattering Sodium Thermal response Thermodynamics Vinculin X-Ray Diffraction X-ray scattering α-Catenin
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