Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008
To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008. Blood specimens were collected from 87 household members and 332 social contacts of 23...
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| Veröffentlicht in: | PloS one 2013-08, Vol.8 (8), p.e71765-e71765 |
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| creator | Liao, Qiaohong Bai, Tian Zhou, Lei Vong, Sirenda Guo, Junqiao Lv, Wei Dong, Libo Xiang, Nijuan Li, Zi Huai, Yang Zhou, Jianfang Li, Xiaodan Chen, Ray Y Xu, Zhen Uyeki, Timothy M Shu, Yuelong Yu, Hongjie |
| description | To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case's infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005-2008 were not easily transmitted to close contacts of H5N1 cases. |
| doi_str_mv | 10.1371/journal.pone.0071765 |
| format | Article |
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Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case's infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005-2008 were not easily transmitted to close contacts of H5N1 cases.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0071765</identifier><identifier>PMID: 23967241</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Antibodies ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Avian flu ; Avian influenza ; Avian influenza viruses ; Biology ; Blood ; Chickens ; Child ; Child, Preschool ; China - epidemiology ; Contact ; Development and progression ; Disease control ; Disease prevention ; Epidemiology ; Erythrocytes ; Exposure ; Family planning ; Female ; Health surveillance ; Hemagglutinins ; Humans ; Illnesses ; Infections ; Infectious diseases ; Influenza ; Influenza A ; Influenza A Virus, H5N1 Subtype - immunology ; Influenza, Human - epidemiology ; Influenza, Human - immunology ; Influenza, Human - transmission ; Lectins ; Male ; Medical laboratories ; Medicine ; Middle Aged ; Personal protective equipment ; Pneumonia ; Population Surveillance ; Poultry ; Protective equipment ; Public health ; Science Policy ; Seroepidemiologic Studies ; Serology ; Systematic review ; Ultrasonic testing ; Virology ; Viruses ; Young Adult</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e71765-e71765</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-6478ebf0100699fff838ef3b0652335c00b26236bd944225f2ded9b55233bc973</citedby><cites>FETCH-LOGICAL-c593t-6478ebf0100699fff838ef3b0652335c00b26236bd944225f2ded9b55233bc973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742513/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742513/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23967241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yen, Hui-Ling</contributor><creatorcontrib>Liao, Qiaohong</creatorcontrib><creatorcontrib>Bai, Tian</creatorcontrib><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Vong, Sirenda</creatorcontrib><creatorcontrib>Guo, Junqiao</creatorcontrib><creatorcontrib>Lv, Wei</creatorcontrib><creatorcontrib>Dong, Libo</creatorcontrib><creatorcontrib>Xiang, Nijuan</creatorcontrib><creatorcontrib>Li, Zi</creatorcontrib><creatorcontrib>Huai, Yang</creatorcontrib><creatorcontrib>Zhou, Jianfang</creatorcontrib><creatorcontrib>Li, Xiaodan</creatorcontrib><creatorcontrib>Chen, Ray Y</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Uyeki, Timothy M</creatorcontrib><creatorcontrib>Shu, Yuelong</creatorcontrib><creatorcontrib>Yu, Hongjie</creatorcontrib><title>Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case's infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005-2008 were not easily transmitted to close contacts of H5N1 cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Avian flu</subject><subject>Avian influenza</subject><subject>Avian influenza viruses</subject><subject>Biology</subject><subject>Blood</subject><subject>Chickens</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Contact</subject><subject>Development and progression</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Epidemiology</subject><subject>Erythrocytes</subject><subject>Exposure</subject><subject>Family planning</subject><subject>Female</subject><subject>Health surveillance</subject><subject>Hemagglutinins</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A Virus, H5N1 Subtype - immunology</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - transmission</subject><subject>Lectins</subject><subject>Male</subject><subject>Medical laboratories</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Personal protective equipment</subject><subject>Pneumonia</subject><subject>Population Surveillance</subject><subject>Poultry</subject><subject>Protective equipment</subject><subject>Public health</subject><subject>Science Policy</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Systematic review</subject><subject>Ultrasonic testing</subject><subject>Virology</subject><subject>Viruses</subject><subject>Young 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Zi</au><au>Huai, Yang</au><au>Zhou, Jianfang</au><au>Li, Xiaodan</au><au>Chen, Ray Y</au><au>Xu, Zhen</au><au>Uyeki, Timothy M</au><au>Shu, Yuelong</au><au>Yu, Hongjie</au><au>Yen, Hui-Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-13</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e71765</spage><epage>e71765</epage><pages>e71765-e71765</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case's infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005-2008 were not easily transmitted to close contacts of H5N1 cases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23967241</pmid><doi>10.1371/journal.pone.0071765</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-08, Vol.8 (8), p.e71765-e71765 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1430434286 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Avian flu Avian influenza Avian influenza viruses Biology Blood Chickens Child Child, Preschool China - epidemiology Contact Development and progression Disease control Disease prevention Epidemiology Erythrocytes Exposure Family planning Female Health surveillance Hemagglutinins Humans Illnesses Infections Infectious diseases Influenza Influenza A Influenza A Virus, H5N1 Subtype - immunology Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - transmission Lectins Male Medical laboratories Medicine Middle Aged Personal protective equipment Pneumonia Population Surveillance Poultry Protective equipment Public health Science Policy Seroepidemiologic Studies Serology Systematic review Ultrasonic testing Virology Viruses Young Adult |
| title | Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008 |
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