Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice
To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity. Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets,...
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| creator | Wanders, Desiree Graff, Emily C White, B Douglas Judd, Robert L |
| description | To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.
Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.
Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.
Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner. |
| doi_str_mv | 10.1371/journal.pone.0071285 |
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Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.
Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.
Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0071285</identifier><identifier>PMID: 23967184</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipocytes ; Adiponectin ; Adiponectin - genetics ; Adiponectin - metabolism ; Adipose tissue ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Anatomy & physiology ; Animals ; Biology ; Body fat ; CD11c antigen ; Chaperones ; Chemokines ; Cholesterol ; Cytokines ; Diabetes ; Diet ; Diet, High-Fat ; Endoplasmic reticulum ; Fatty acids ; Gene expression ; Gene Expression Regulation - drug effects ; Genes ; High fat diet ; House mouse ; IL-1β ; Inflammation ; Insulin ; Laboratories ; Lipids ; Low density lipoprotein ; Macrophages ; Macrophages - metabolism ; Male ; Mathematics ; Medicine ; Metabolic syndrome ; Mice ; Mice, Knockout ; Molecular Chaperones - genetics ; Molecular Chaperones - metabolism ; Monocyte chemoattractant protein 1 ; Niacin ; Niacin - metabolism ; Niacin - pharmacology ; Nutrition research ; Obesity ; Panniculitis - genetics ; Panniculitis - metabolism ; Pharmacology ; Physiology ; Proteins ; Rodents ; Sterol regulatory element-binding protein ; Transcription (Genetics) ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Veterinary colleges ; Veterinary medicine ; Vitamin B ; Weight control</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e71285</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Wanders et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Wanders et al 2013 Wanders et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-4bda8a5821dff89976674cfff9fe479f9f8535c27bfd339971c7bee0ce2f06d23</citedby><cites>FETCH-LOGICAL-c743t-4bda8a5821dff89976674cfff9fe479f9f8535c27bfd339971c7bee0ce2f06d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742781/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742781/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23967184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wanders, Desiree</creatorcontrib><creatorcontrib>Graff, Emily C</creatorcontrib><creatorcontrib>White, B Douglas</creatorcontrib><creatorcontrib>Judd, Robert L</creatorcontrib><title>Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.
Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.
Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.
Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.</description><subject>Adipocytes</subject><subject>Adiponectin</subject><subject>Adiponectin - genetics</subject><subject>Adiponectin - metabolism</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biology</subject><subject>Body fat</subject><subject>CD11c antigen</subject><subject>Chaperones</subject><subject>Chemokines</subject><subject>Cholesterol</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Endoplasmic reticulum</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes</subject><subject>High fat diet</subject><subject>House mouse</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Laboratories</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medicine</subject><subject>Metabolic syndrome</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - metabolism</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Niacin</subject><subject>Niacin - metabolism</subject><subject>Niacin - pharmacology</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Panniculitis - genetics</subject><subject>Panniculitis - metabolism</subject><subject>Pharmacology</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Sterol regulatory element-binding protein</subject><subject>Transcription (Genetics)</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><subject>Vitamin B</subject><subject>Weight control</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLwoIXHfPVJr0RlmXVgcUFv25jmpzMZGib2SYV_femTneZgoLkIuGc530T3pwse47RClOO3-z8OPSqXe19DyuEOCaifJCd4pqSoiKIPjw6n2RPQtghVFJRVY-zE0LrimPBTrPvH53Srs9drwdQAUKujJssdUxV1ZvcwKITII8uhBGSxLaq61R0ftLnW7fZ5lbF3DiIhQWTd07D0-yRVW2AZ_N-ln19d_Xl8kNxffN-fXlxXWjOaCxYY5RQpSDYWCvqmlcVZ9paW1tgvE6bKGmpCW-soTT1seYNANJALKoMoWfZy4PvvvVBzuEEiRlFjDLMUSLWB8J4tZP7wXVq-CW9cvJPwQ8bqYbodAsSY9vUQkNVasOEbhqOLK6BG1WVlTYqeb2dbxubDoyGPg6qXZguO73byo3_ISlnhAucDF7NBoO_HSHEfzx5pjYqvSoF7pOZ7lzQ8oJxQWpB6ESt_kKlZSD9QPpL61J9IXi9ECQmws-4UWMIcv350_-zN9-W7PkRuwXVxm3w7ThNSFiC7ADqwYcwgL1PDiM5TfddGnIaRTlPd5K9OE79XnQ3zvQ3-GP2og</recordid><startdate>20130813</startdate><enddate>20130813</enddate><creator>Wanders, Desiree</creator><creator>Graff, Emily C</creator><creator>White, B Douglas</creator><creator>Judd, Robert L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130813</creationdate><title>Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice</title><author>Wanders, Desiree ; Graff, Emily C ; White, B Douglas ; Judd, Robert L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-4bda8a5821dff89976674cfff9fe479f9f8535c27bfd339971c7bee0ce2f06d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipocytes</topic><topic>Adiponectin</topic><topic>Adiponectin - genetics</topic><topic>Adiponectin - metabolism</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biology</topic><topic>Body fat</topic><topic>CD11c antigen</topic><topic>Chaperones</topic><topic>Chemokines</topic><topic>Cholesterol</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Endoplasmic reticulum</topic><topic>Fatty acids</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes</topic><topic>High fat diet</topic><topic>House mouse</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Laboratories</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Mathematics</topic><topic>Medicine</topic><topic>Metabolic syndrome</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Chaperones - 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Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.
Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.
Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23967184</pmid><doi>10.1371/journal.pone.0071285</doi><tpages>e71285</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2013-08, Vol.8 (8), p.e71285 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adipocytes Adiponectin Adiponectin - genetics Adiponectin - metabolism Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Anatomy & physiology Animals Biology Body fat CD11c antigen Chaperones Chemokines Cholesterol Cytokines Diabetes Diet Diet, High-Fat Endoplasmic reticulum Fatty acids Gene expression Gene Expression Regulation - drug effects Genes High fat diet House mouse IL-1β Inflammation Insulin Laboratories Lipids Low density lipoprotein Macrophages Macrophages - metabolism Male Mathematics Medicine Metabolic syndrome Mice Mice, Knockout Molecular Chaperones - genetics Molecular Chaperones - metabolism Monocyte chemoattractant protein 1 Niacin Niacin - metabolism Niacin - pharmacology Nutrition research Obesity Panniculitis - genetics Panniculitis - metabolism Pharmacology Physiology Proteins Rodents Sterol regulatory element-binding protein Transcription (Genetics) Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Veterinary colleges Veterinary medicine Vitamin B Weight control |
| title | Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice |
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