Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells

Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We hypothesized that TFAM, bound to mtDNA (or equivalent CpG-enriched DNA), amplifies TNFα release from TLR9-expressing plasmacytoid dendritic cell...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72354-e72354
Hauptverfasser:	Julian, Mark W, Shao, Guohong, Vangundy, Zachary C, Papenfuss, Tracey L, Crouser, Elliott D
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acidification Animals Anticoagulants Cell culture Cell interactions Cell Line Converting CpG Islands Critical care Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Deoxyribonucleic acid DNA DNA, Mitochondrial - immunology DNA, Mitochondrial - metabolism DNA-Binding Proteins - metabolism Endosomes Endothelin Endothelins Enzyme-linked immunosorbent assay Enzymes Equivalence FLT3L protein Hazards Heparin HMGB1 Protein - metabolism HMGB2 Protein - metabolism Humans Illnesses Immune response In vivo methods and tests Inflammation Ischemia Kinases Laboratory animals Male Mice Mitochondrial DNA Mitochondrial Proteins - metabolism Mitogen-Activated Protein Kinases - metabolism Models, Biological Multiple organ dysfunction syndrome NF-kappa B - metabolism NF-κB protein Oligonucleotides Phosphatidylinositol 3-Kinases - metabolism Pretreatment Protein Binding Proteins Receptors Recognition Signal Transduction Signaling Sleep Spleen - cytology Spleen - metabolism Splenocytes Sulfate Sulfates TLR9 protein Toll-Like Receptor 9 - metabolism Toll-like receptors Transcription factors Transcription Factors - metabolism Trauma Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Veterinary colleges Veterinary medicine
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