cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia

The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP). We investigated the associations between cAMP, myopia development in guinea pigs, and co...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71441
Hauptverfasser:	Tao, Yijin, Pan, Miaozhen, Liu, Shufeng, Fang, Fang, Lu, Runxia, Lu, Chanyi, Zheng, Min, An, Jianhong, Xu, Hongjia, Zhao, Fuxin, Chen, Jiang-Fan, Qu, Jia, Zhou, Xiangtian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine monophosphate Analysis Animal models Animals Biology Colforsin - adverse effects Colforsin - pharmacology Collagen Collagen - genetics Collagen - metabolism Cyclic adenosine monophosphate Cyclic AMP Cyclic AMP - metabolism Electroretinograms Extracellular matrix Eye (anatomy) Fibroblasts Forskolin Gene expression Gene Expression Regulation - drug effects Guinea Pigs Hospitals Intraocular Pressure - drug effects Kinases Laboratories Masking Medicine mRNA Myopia Myopia - chemically induced Myopia - genetics Myopia - metabolism Optometry Retina Retina - drug effects Retina - metabolism RNA Science Sclera - metabolism Secretion Sensory Deprivation Synthesis
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