The severity of nocturnal hypoxia but not abdominal adiposity is associated with insulin resistance in non-obese men with sleep apnea
Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients. The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdomina...
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| Veröffentlicht in: | PloS one 2013-08, Vol.8 (8), p.e71000-e71000 |
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| creator | Borel, Anne-Laure Monneret, Denis Tamisier, Renaud Baguet, Jean-Philippe Faure, Patrice Levy, Patrick Halimi, Serge Pépin, Jean-Louis |
| description | Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients.
The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdominal adiposity to the cardiometabolic risk profile of 38 non obese men with polysomnography-diagnosed sleep apnea syndrome (apnea-hypopnea index >15 events/hour). These otherwise healthy men performed a 75g-oral glucose tolerance test (OGTT) with plasma lipid/inflammatory and redox profiles. Twenty-one apneic men with high-waist circumference (>94 cm) were compared to 17 apneic men with low-waist circumference.
Apneic men with high-waist circumference had higher AUC glucose and AUC insulin than apneic men with low-waist circumference. Accordingly, apneic men with high-waist circumference had higher hepatic insulin resistance as reflected by higher HOMA-resistance index, and lower global insulin sensitivity as reflected by lower insulin sensitivity index of Matsuda (derived from OGTT). The sleep structure and the apnea-hypopnea index were not different between the two groups. However, apneic men with high-waist circumference presented with lower mean nocturnal oxyhemoglobin (SpO2). In the 38 men, waist circumference and mean nocturnal SpO2 were inversely correlated (r = -0.43, p = 0.011) and were both associated with plasma glucose/insulin homeostasis indices: the higher the waist circumference, the lower the mean nocturnal SpO2, the lower the insulin-sensitivity. Finally, in multivariable regression model, mean nocturnal SpO2 and not waist circumference was associated with insulin-resistance.
Thus, excess abdominal adiposity in non obese apneic men was associated with a deteriorated insulin-sensitivity that could be driven by a more severe nocturnal hypoxemia. |
| doi_str_mv | 10.1371/journal.pone.0071000 |
| format | Article |
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The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdominal adiposity to the cardiometabolic risk profile of 38 non obese men with polysomnography-diagnosed sleep apnea syndrome (apnea-hypopnea index >15 events/hour). These otherwise healthy men performed a 75g-oral glucose tolerance test (OGTT) with plasma lipid/inflammatory and redox profiles. Twenty-one apneic men with high-waist circumference (>94 cm) were compared to 17 apneic men with low-waist circumference.
Apneic men with high-waist circumference had higher AUC glucose and AUC insulin than apneic men with low-waist circumference. Accordingly, apneic men with high-waist circumference had higher hepatic insulin resistance as reflected by higher HOMA-resistance index, and lower global insulin sensitivity as reflected by lower insulin sensitivity index of Matsuda (derived from OGTT). The sleep structure and the apnea-hypopnea index were not different between the two groups. However, apneic men with high-waist circumference presented with lower mean nocturnal oxyhemoglobin (SpO2). In the 38 men, waist circumference and mean nocturnal SpO2 were inversely correlated (r = -0.43, p = 0.011) and were both associated with plasma glucose/insulin homeostasis indices: the higher the waist circumference, the lower the mean nocturnal SpO2, the lower the insulin-sensitivity. Finally, in multivariable regression model, mean nocturnal SpO2 and not waist circumference was associated with insulin-resistance.
Thus, excess abdominal adiposity in non obese apneic men was associated with a deteriorated insulin-sensitivity that could be driven by a more severe nocturnal hypoxemia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0071000</identifier><identifier>PMID: 23951064</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdominal Fat ; Adipose tissue ; Adiposity ; Adult ; Apnea ; Biology ; Body Composition ; Body Mass Index ; Comparative analysis ; Endocrinology and metabolism ; Glucose ; Glucose tolerance ; Glucose Tolerance Test ; Health risk assessment ; Health risks ; Homeostasis ; Human health and pathology ; Humans ; Hypoxemia ; Hypoxia ; Inflammation ; Insulin ; Insulin Resistance ; Life Sciences ; Male ; Medical research ; Medicine ; Men ; Middle Aged ; Obesity ; Oxyhemoglobin ; Polysomnography ; Regression models ; Risk assessment ; Risk Factors ; Sensitivity ; Sleep ; Sleep apnea ; Sleep Apnea Syndromes - blood ; Sleep Apnea Syndromes - metabolism ; Sleep Apnea Syndromes - physiopathology ; Sleep disorders</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e71000-e71000</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Borel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2013 Borel et al 2013 Borel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-125d27d0bf8e4ef51f0b40b4c367aefd828c4a07c0f1aac92ca00f90713da8dd3</citedby><cites>FETCH-LOGICAL-c726t-125d27d0bf8e4ef51f0b40b4c367aefd828c4a07c0f1aac92ca00f90713da8dd3</cites><orcidid>0000-0003-3832-2358 ; 0000-0003-1128-6529</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741390/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741390/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23951064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-01537927$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Borel, Anne-Laure</creatorcontrib><creatorcontrib>Monneret, Denis</creatorcontrib><creatorcontrib>Tamisier, Renaud</creatorcontrib><creatorcontrib>Baguet, Jean-Philippe</creatorcontrib><creatorcontrib>Faure, Patrice</creatorcontrib><creatorcontrib>Levy, Patrick</creatorcontrib><creatorcontrib>Halimi, Serge</creatorcontrib><creatorcontrib>Pépin, Jean-Louis</creatorcontrib><title>The severity of nocturnal hypoxia but not abdominal adiposity is associated with insulin resistance in non-obese men with sleep apnea</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients.
The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdominal adiposity to the cardiometabolic risk profile of 38 non obese men with polysomnography-diagnosed sleep apnea syndrome (apnea-hypopnea index >15 events/hour). These otherwise healthy men performed a 75g-oral glucose tolerance test (OGTT) with plasma lipid/inflammatory and redox profiles. Twenty-one apneic men with high-waist circumference (>94 cm) were compared to 17 apneic men with low-waist circumference.
Apneic men with high-waist circumference had higher AUC glucose and AUC insulin than apneic men with low-waist circumference. Accordingly, apneic men with high-waist circumference had higher hepatic insulin resistance as reflected by higher HOMA-resistance index, and lower global insulin sensitivity as reflected by lower insulin sensitivity index of Matsuda (derived from OGTT). The sleep structure and the apnea-hypopnea index were not different between the two groups. However, apneic men with high-waist circumference presented with lower mean nocturnal oxyhemoglobin (SpO2). In the 38 men, waist circumference and mean nocturnal SpO2 were inversely correlated (r = -0.43, p = 0.011) and were both associated with plasma glucose/insulin homeostasis indices: the higher the waist circumference, the lower the mean nocturnal SpO2, the lower the insulin-sensitivity. Finally, in multivariable regression model, mean nocturnal SpO2 and not waist circumference was associated with insulin-resistance.
Thus, excess abdominal adiposity in non obese apneic men was associated with a deteriorated insulin-sensitivity that could be driven by a more severe nocturnal hypoxemia.</description><subject>Abdominal Fat</subject><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Apnea</subject><subject>Biology</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Comparative analysis</subject><subject>Endocrinology and metabolism</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Homeostasis</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hypoxemia</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Oxyhemoglobin</subject><subject>Polysomnography</subject><subject>Regression models</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Sensitivity</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea Syndromes - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borel, Anne-Laure</au><au>Monneret, Denis</au><au>Tamisier, Renaud</au><au>Baguet, Jean-Philippe</au><au>Faure, Patrice</au><au>Levy, Patrick</au><au>Halimi, Serge</au><au>Pépin, Jean-Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The severity of nocturnal hypoxia but not abdominal adiposity is associated with insulin resistance in non-obese men with sleep apnea</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-12</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e71000</spage><epage>e71000</epage><pages>e71000-e71000</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients.
The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdominal adiposity to the cardiometabolic risk profile of 38 non obese men with polysomnography-diagnosed sleep apnea syndrome (apnea-hypopnea index >15 events/hour). These otherwise healthy men performed a 75g-oral glucose tolerance test (OGTT) with plasma lipid/inflammatory and redox profiles. Twenty-one apneic men with high-waist circumference (>94 cm) were compared to 17 apneic men with low-waist circumference.
Apneic men with high-waist circumference had higher AUC glucose and AUC insulin than apneic men with low-waist circumference. Accordingly, apneic men with high-waist circumference had higher hepatic insulin resistance as reflected by higher HOMA-resistance index, and lower global insulin sensitivity as reflected by lower insulin sensitivity index of Matsuda (derived from OGTT). The sleep structure and the apnea-hypopnea index were not different between the two groups. However, apneic men with high-waist circumference presented with lower mean nocturnal oxyhemoglobin (SpO2). In the 38 men, waist circumference and mean nocturnal SpO2 were inversely correlated (r = -0.43, p = 0.011) and were both associated with plasma glucose/insulin homeostasis indices: the higher the waist circumference, the lower the mean nocturnal SpO2, the lower the insulin-sensitivity. Finally, in multivariable regression model, mean nocturnal SpO2 and not waist circumference was associated with insulin-resistance.
Thus, excess abdominal adiposity in non obese apneic men was associated with a deteriorated insulin-sensitivity that could be driven by a more severe nocturnal hypoxemia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23951064</pmid><doi>10.1371/journal.pone.0071000</doi><orcidid>https://orcid.org/0000-0003-3832-2358</orcidid><orcidid>https://orcid.org/0000-0003-1128-6529</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-08, Vol.8 (8), p.e71000-e71000 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1430420710 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abdominal Fat Adipose tissue Adiposity Adult Apnea Biology Body Composition Body Mass Index Comparative analysis Endocrinology and metabolism Glucose Glucose tolerance Glucose Tolerance Test Health risk assessment Health risks Homeostasis Human health and pathology Humans Hypoxemia Hypoxia Inflammation Insulin Insulin Resistance Life Sciences Male Medical research Medicine Men Middle Aged Obesity Oxyhemoglobin Polysomnography Regression models Risk assessment Risk Factors Sensitivity Sleep Sleep apnea Sleep Apnea Syndromes - blood Sleep Apnea Syndromes - metabolism Sleep Apnea Syndromes - physiopathology Sleep disorders |
| title | The severity of nocturnal hypoxia but not abdominal adiposity is associated with insulin resistance in non-obese men with sleep apnea |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T17%3A19%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20severity%20of%20nocturnal%20hypoxia%20but%20not%20abdominal%20adiposity%20is%20associated%20with%20insulin%20resistance%20in%20non-obese%20men%20with%20sleep%20apnea&rft.jtitle=PloS%20one&rft.au=Borel,%20Anne-Laure&rft.date=2013-08-12&rft.volume=8&rft.issue=8&rft.spage=e71000&rft.epage=e71000&rft.pages=e71000-e71000&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0071000&rft_dat=%3Cgale_plos_%3EA478310977%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1430420710&rft_id=info:pmid/23951064&rft_galeid=A478310977&rft_doaj_id=oai_doaj_org_article_695239ec402345239c1c5ca79d358352&rfr_iscdi=true |